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Original Article from The New England Journal of Medicine — Overexpression of the Cytokine BAFF and Autoimmunity Risk
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Scooped by Gilbert C FAURE |
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Gilbert C FAURE's insight:
in Sardinia
A variant in TNFSF13B, encoding the cytokine and drug target B-cell activating factor (BAFF), was associated with multiple sclerosis as well as SLE. The disease-risk allele was also associated with up-regulated humoral immunity through increased levels of soluble BAFF, B lymphocytes, and immunoglobulins. The causal variant was identified: an insertion–deletion variant, GCTGT→A (in which A is the risk allele), yielded a shorter transcript that escaped microRNA inhibition and increased production of soluble BAFF, which in turn up-regulated humoral immunity. Population genetic signatures indicated that this autoimmunity variant has been evolutionarily advantageous, most likely by augmenting resistance to malaria.
Baff in topic
http://www.scoop.it/t/autoimmunity?q=baff
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