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With the conceptual advance about four decades ago that type 1 diabetes represents 
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The nuclear receptor retinoic acid–related orphan receptor (ROR)t is required for the generation of Th17 cells, which are involved in various autoimmune diseases, including Sjögren’s syndrome (SS).
Gilbert C FAURE's insight:
However, the pathological role of RORγt in SS remains to be elucidated. The present study was designed to clarify the role of RORγt in the pathogenesis of sialadenitis-like SS. Histological analysis of RORγt transgenic (Tg) mice was determined, and then Tg mice developed severe spontaneous sialadenitis-like SS. The analysis of infiltrating cells showed that most infiltrating cells were CD4+ T cells. RORγt-overexpressing CD4+ T cells induced sialadenitis as a result of transferred CD4+ T cells from Tg mice into Rag2−/− mice. The examination of IL-17–deficient Tg mice indicated that IL-17 was not essential for the development of sialadenitis. The number of CD4+CD25+Foxp3+ regulatory T (Treg) cells was significantly decreased in Tg mice, and CD25 expression and IL-2 stimulated STAT5 activation were inhibited in Treg cells. The inhibitory function of Treg cells of Tg mice was equal to that of wild-type mice in vitro. The abundant Treg cells of Tg mice could suppress the development of sialadenitis, but the reduced Treg cells of Tg mice could not inhibit the induction of sialadenitis in Rag2−/− mice transferred with effector cells from Tg mice. These results suggest that both RORγt-overexpressed CD4+ T cells and reduced Treg cells might contribute to the development of SS-like sialadenitis.
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Here we report that proliferation of Treg cells after TCR stimulation is impaired in subjects with relapsing-remitting multiple sclerosis (RRMS) because of altered interleukin-2 (IL-2) secretion and IL-2 receptor (IL-2R)-signal ... Via Krishan Maggon , Alfredo Corell
Alfredo Corell's curator insight,
December 13, 2013 12:42 PM
Original article: http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3411.html NATURE MEDICINE | LETTER Regulatory T cell proliferative potential is impaired in human autoimmune diseaseFortunata Carbone,Veronica De Rosa,Pietro B Carrieri,Silvana Montella,Dario Bruzzese,Antonio Porcellini,Claudio Procaccini,Antonio La Cava& Giuseppe Matarese |
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New research may help explain why dietary changes are often effective when treating inflammatory conditions.
Gilbert C FAURE's insight:
two days ago on scoop.it autoimmunity
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Regulatory T cells (Tregs) mediate immune tolerance to self and depend on IL-2 for homeostasis. Treg deficiency, dysfunction, and instability are implicated in the pathogenesis of numerous autoimmune diseases.
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from clinic to therapies
https://www.scoop.it/t/autoimmunity?q=diabetes