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Scoop.it!
Sequencing DNA from individual cells is changing the way that researchers think of humans as a whole. 
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Scoop.it!
The full lecture title is "Cancers - Their Genomes, Microenvironments, and Susceptibility to Bacteria-based Therapies" by Bert Vogelstein. The Johns Hopkins Center for Biotechnology Education and the Department of Biology in the Krieger School of Arts and Sciences hosted the American Society for Microbiology's Conference for Undergraduate Educators (ASMCUE) on the Homewood campus. Bert Vogelstein gave the closing plenary lecture, "Cancers - Their Genomes, Microenvironments, and Susceptibility to Bacteria-based Therapies". He teaches at John Hopkins University. Via Dr. Stefan Gruenwald
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Human genomes such as cancer have been traditionally sequenced from DNA extracted from multiple cells. With certain cancers we know that local individual cellular adaptations, mutations and variation impact gene expression, cell behaviour and drug response. Nicholas Navin pioneered a new approach for single cell sequencing pioneered in order to sequence individual cancer cells and map local mutations and adaptations. Timour Basian and team inspired by Navin's work, helped perfect techniques for single cell sequencing while dramatically reduced sequencing pricing from $1000 per single cell to approx $60 per cell. The article discuses further developments, implications and potential opportunities created by the advent of single cell sequencing. Worth reading.