Authers investigate the in vivo effect of FGF-2 overexpression on axonal regeneration after nerve injury. They transduced Schwann cells with LV-FGF2 which were grafted to repair the resected rat sciatic nerve. Electrophysiological tests conducted for up to 2 months after injury revealed accelerated and more marked reinnervation of hindlimb muscles in the animals treated with LV-FGF2, with an increase in the number of motor and sensory neurons that reached the distal tibial nerve at the end of follow-up.
Authers investigate the in vivo effect of FGF-2 overexpression on axonal regeneration after nerve injury. They transduced Schwann cells with LV-FGF2 which were grafted to repair the resected rat sciatic nerve. Electrophysiological tests conducted for up to 2 months after injury revealed accelerated and more marked reinnervation of hindlimb muscles in the animals treated with LV-FGF2, with an increase in the number of motor and sensory neurons that reached the distal tibial nerve at the end of follow-up.
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Authers investigate the in vivo effect of FGF-2 overexpression on axonal regeneration after nerve injury. They transduced Schwann cells with LV-FGF2 which were grafted to repair the resected rat sciatic nerve. Electrophysiological tests conducted for up to 2 months after injury revealed accelerated and more marked reinnervation of hindlimb muscles in the animals treated with LV-FGF2, with an increase in the number of motor and sensory neurons that reached the distal tibial nerve at the end of follow-up.
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