Scientists have shown that misfolded islet amyloid polypeptide aggregates are transmissible like prions and can trigger the development of type 2 diabetes pathogenesis in the recipient
WASHINGTON (AP) — Federal regulators have approved a first-of-a-kind "artificial pancreas," a device that can help some diabetes patients manage their disease by constantly monitoring their blood sugar and delivering insulin as needed.
BigField GEG Tech's insight:
Federal regulators have approved a first-of-a-kind "artificial pancreas," a device that can help some diabetes patients manage their disease by constantly monitoring their blood sugar and delivering insulin as needed.
French pharmaceutical group Sanofi is joining with Verily Life Sciences, a unit of Google parent Alphabet, to create a joint venture called Onduo to research diabetes treatments.
metformin and glycoside - and then I was able to just continue taking those for months until I saw a consultant who then said that my diabetes had got worse. So I was actually diagnosed as type 1 then and introduced to insulin," he explained.
BigField GEG Tech's insight:
Correctly diagnosing which type of diabete a patient has is crucial, and in a small minority of cases the wrong diagnosis can be fatal. But in an age of growing obesity in the western world, diagnosis is becoming increasingly difficult for doctors.
According to diabetes expert Dr Richard Oram, from the University of Exeter Medical School, clinical diagnosis is currently based almost entirely on age at diagnosis and whether a patient is obese.
Oram's team has come up with a new, relatively inexpensive, genetic test for the disease, which he thinks will help doctors.
Common diabetes drugs might help eradicate drug-resistant cancer cells in a certain form of leukemia when added to standard treatment, a small new study suggests.
Nanoengineers at the University of California, San Diego have tested a temporary tattoo that both extracts and measures the level of glucose in the fluid in between skin cells. This first-ever example of the flexible, easy-to-wear device could be a promising step forward in noninvasive glucose testing for patients with diabetes.
This study points out that the GAD65 protein unpredictable behavior much like Dr. Jekyll and Mr. Hyde. Indeed this protein is essential to the synthesis of some neurotransmitters but could be also presents in the pancreas where it could induce diabete of type 1.
FDA-approved artemisinins, which have been used for decades to treat malaria, transform glucagon-producing alpha cells in the pancreas into insulin producing cells, researchers report.
University of Utah researchers have found that the structure of an insulin molecule produced by predatory cone snails may be an improvement over current fast-acting therapeutic insulin. The finding suggests that the cone snail insulin, produced by the snails to stun their prey, could begin working in as few as five minutes, compared with 15 minutes for the fastest-acting insulin currently available. Biologist Helena Safavi, co-author on a paper describing the cone snail insulin published September 12 in Nature Structural & Molecular Biology, says that studying complex venom cocktails can open doors to new drug discoveries.
French researchers have modified a molecule used in the treatment of diabetes to destroy melanoma. This strategy could be used for patients resistant to current therapies.
Diabetes often referred to by doctors as diabetes mellitus is considered to be one of the leading causes of death. Having this kind of disease doubles your chance of acquiring heart attack. Knowledge about the disease will prevent someone from getting it or it can lessen the risks for diabetes complications. There has been several ways in detecting if someone suffers from it.
To investigate the roles and therapeutic potential for targeting the RORs in type 1 diabetes, the scientists administered SR1001, a selective RORα/γ inverse agonist, to non-obese diabetic (NOD) mice. SR1001 significantly reduced diabetes incidence and insulitis in treated mice. Furthermore, SR1001 reduced pro-inflammatory cytokine expression, particularly TH17-mediated cytokines, reduced autoantibody production, and increased the frequency of CD4+Foxp3+ T regulatory cells.
New ground-breaking genetics research explains the high incidence of type 2 diabetes in the Greenlandic population, based on blood samples from 5,000 people or approximately 10% of the population. "Several epidemiological studies have looked at the health implications of the transition from life as sealers and hunters in small isolated communities to a modern lifestyle with appreciable dietary changes. Perhaps the gene variant which has been identified can be interpreted as a sign of natural selection as the traditional Greenlandic diet consisted primarily of protein and fat from sea animals," one researcher said.
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Scientists have shown that misfolded islet amyloid polypeptide aggregates are transmissible like prions and can trigger the development of type 2 diabetes pathogenesis in the recipient