An efficient process to rapidly discover new “enediyne natural products” from soil microbes has now been developed that could be further developed into extremely potent anticancer drugs, researchers report.
Bioengineers have converted a protein pathway found in freshwater photosynthetic bacteria into the first engineered transcriptional regulatory tool that is activated exclusively by UV-violet light. The tool could make the manufacture of drugs and other substances by engineered bacteria more efficient.
The scientists report a method to convert discrete representations of molecules to and from a multidimensional continuous representation. This generative model allows efficient search and optimization through open-ended spaces of chemical compounds.
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An efficient process to rapidly discover new “enediyne natural products” from soil microbes has now been developed that could be further developed into extremely potent anticancer drugs, researchers report.