Analysis of nascent RNA identifies a unified architecture of initiation regions at mammalian promoters and enhancers - Nature Genetics | Bioscience News - GEG Tech top picks | Scoop.it
John Lis, Adam Siepel and colleagues map transcription start sites across the genome in two human cell lines using a nuclear run-on protocol called GRO-cap. They find a common architecture of initiation at both promoters and enhancers and that transcript elongation stability provides the strongest distinction between promoters and enhancers.