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Star-shaped engineered peptide nanoparticles are effective at killing a variety of multidrug-resistant Gram-negative pathogens in vivo with low host toxicity and resistance.
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Here, the authors show that a class of antimicrobial agents, termed ‘structurally nanoengineered antimicrobial peptide polymers’ (SNAPPs) exhibit sub-μM activity against all Gram-negative bacteria tested, including ESKAPE and colistin-resistant and MDR (CMDR) pathogens, while demonstrating low toxicity.