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Bioscience News - GEG Tech top picks
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Hidden cell sub-populations are detected by accounting for confounding variation in the analysis of single-cell RNA-seq data.
BigField GEG Tech's insight:
A new method helps scientists create a more accurate picture of gene expression in different cell types, and reveals hidden subtypes of cells. 
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Scoop.it!
BigField GEG Tech's insight:
This new study demonstrates a method of barcoding cells multiple times and then sequencing them. The method greatly expands the number of single cells that can be mapped. The findings from this study were published recently in Nature Methods in an article entitled “Sequencing Thousands of Single-Cell Genomes with Combinatorial Indexing.”
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Think of life as a house: if DNA molecules are blueprints, then messenger RNAs (mRNAs) are orders, describing the required parts (proteins) and when they should arrive. But putting in many orders doesn’t always mean you’ll get all of the parts on time — maybe there’s a delay with your vendor or delivery service. Similarly, mRNA levels alone do not dictate protein levels