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TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis - Science

TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis - Science | Bioscience News - GEG Tech top picks | Scoop.it
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A new drug, OTS964, can eradicate aggressive human lung cancers transplanted into mice, scientists report. It inhibits the action of a protein that is overproduced by several tumor types but is rarely expressed in healthy adult tissues. Without it, cancer cells fail to complete the cell-division process and die.


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Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways - Cell

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways - Cell | Bioscience News - GEG Tech top picks | Scoop.it
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The researchers show that stromal and breast cancer (BrCa) cells utilize paracrine and juxtacrine signaling to drive chemotherapy and radiation resistance.


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Organelle-Based Aggregation and Retention of Damaged Proteins in Asymmetrically Dividing Cells - Cell

Organelle-Based Aggregation and Retention of Damaged Proteins in Asymmetrically Dividing Cells - Cell | Bioscience News - GEG Tech top picks | Scoop.it
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Dicer Promotes Transcription Termination at Sites of Replication Stress to Maintain Genome Stability - Cell

Dicer Promotes Transcription Termination at Sites of Replication Stress to Maintain Genome Stability - Cell | Bioscience News - GEG Tech top picks | Scoop.it
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▶ North Carolina's first retinal prosthesis at Duke Eye Center

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Larry Hester, 66, has been blind for half his life from a condition called retinitis pigmentosa. In September, 2014, an electronic stimulator was surgically implanted in his left eye. On October 1st, 2014 Duke eye surgeon Dr. Paul Hahn turned it on for the first time. While the device does not restore vision in the normal sense, it provides light-and-darkness differentiation.

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The ISME Journal - Microbial degradation of isosaccharinic acid at high pH

The ISME Journal - Microbial degradation of isosaccharinic acid at high pH | Bioscience News - GEG Tech top picks | Scoop.it
The ISME Journal: Multidisciplinary Journal of Microbial Ecology is the official Journal of the International Society for Microbial Ecology, publishing high-quality, original research papers, short communications, commentary articles and reviews in the rapidly expanding and diverse discipline of microbial ecology.
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Medicine Nobel Prize goes for work on cells that form brain's GPS system

Medicine Nobel Prize goes for work on cells that form brain's GPS system | Bioscience News - GEG Tech top picks | Scoop.it
The Nobel Prize in Physiology or Medicine goes to John O'Keefe and May-Britt and Edvard Moser for work on cells that form a positioning system in the brain
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Researchers discover how circular RNA is created, find link to degenerative disease

Researchers discover how circular RNA is created, find link to degenerative disease | Bioscience News - GEG Tech top picks | Scoop.it
Our genetic information is stored in DNA, tiny strands of nucleic acid that contain instructions for the functioning of our bodies. To express this genetic data, our DNA is copied into RNA molecules, which then translate the instructions into proteins that perform tasks in our cells. In addition to known RNAs, circRNA molecules are abundant, yet little has been known about how they are produced, and next to nothing has been known about the role they play in disease. Now, researchers have discovered how circRNAs are produced.
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Steroid hormone signalling links reproduction to lifespan in dietary-restricted Caenorhabditis elegans

Steroid hormone signalling links reproduction to lifespan in dietary-restricted Caenorhabditis elegans | Bioscience News - GEG Tech top picks | Scoop.it

http://www.nature.com/ncomms/2014/140911/ncomms5879/full/ncomms5879.html

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» Translarna Press Release -First ever treatment for rare muscle wasting condition, Duchenne Muscular Dystrophy, given conditional approval by the European Commission Action Duchenne

» Translarna Press Release -First ever treatment for rare muscle wasting condition, Duchenne Muscular Dystrophy, given conditional approval by the European Commission Action Duchenne | Bioscience News - GEG Tech top picks | Scoop.it
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A Genome-Wide Survey of Sexually Dimorphic Expression of Drosophila miRNAs Identifies the Steroid Hormone-Induced miRNA let-7 as a Regulator of Sexual Identity

A Genome-Wide Survey of Sexually Dimorphic Expression of Drosophila miRNAs Identifies the Steroid Hormone-Induced miRNA let-7 as a Regulator of Sexual Identity | Bioscience News - GEG Tech top picks | Scoop.it
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Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice: Cell

Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice: Cell | Bioscience News - GEG Tech top picks | Scoop.it
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Blood cells are new, unexpected source of neurons in crayfish

Blood cells are new, unexpected source of neurons in crayfish | Bioscience News - GEG Tech top picks | Scoop.it
Researchers have strived to determine how neurons are produced and integrated into the brain throughout adult life. In an intriguing twist, scientists provide evidence that adult-born neurons are derived from a special type of circulating blood cell produced by the immune system. The findings -- which were made in crayfish -- suggest that the immune system may contribute to the development of the unknown role of certain brain diseases in the development of brain and other tissues.
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Paper-Based Synthetic Gene Networks could enable rapid detection of ebola and other viruses - Cell

Paper-Based Synthetic Gene Networks could enable rapid detection of ebola and other viruses - Cell | Bioscience News - GEG Tech top picks | Scoop.it
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Computational design of water-soluble α-helical barrels - Science

Computational design of water-soluble α-helical barrels - Science | Bioscience News - GEG Tech top picks | Scoop.it
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Paralysed man Darek Fidyka walks again after pioneering surgery

Paralysed man Darek Fidyka walks again after pioneering surgery | Bioscience News - GEG Tech top picks | Scoop.it
Medical team regrow cells of patient’s severed spine in breakthrough that offers hope to millions with disability
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Key moment mapped in assembly of DNA-splitting molecular machine

Key moment mapped in assembly of DNA-splitting molecular machine | Bioscience News - GEG Tech top picks | Scoop.it
Scientists reveal crucial steps and surprising structures in the genesis of the enzyme that divides the DNA double helix during cell replication. The research combined electron microscopy, perfectly distilled proteins, and a method of chemical freezing to isolate specific moments at the start of replication.
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Scientific Contests > BioArt > 2014 BioArt Winners

Scientific Contests > BioArt > 2014 BioArt Winners | Bioscience News - GEG Tech top picks | Scoop.it
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Eat More Meat, Get Lower Blood Pressure?

Eat More Meat, Get Lower Blood Pressure? | Bioscience News - GEG Tech top picks | Scoop.it
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Nucleosomal regulation of chromatin composition and nuclear assembly revealed by histone depletion - Nature Structural

Nucleosomal regulation of chromatin composition and nuclear assembly revealed by histone depletion - Nature Structural | Bioscience News - GEG Tech top picks | Scoop.it
A new system to monitor the effects of nucleosome depletion in Xenopus egg extracts reveals that nucleosomes are required for spindle assembly and for recruitment of nuclear pore complex (NPC) components to the nuclear envelope for NPC formation.
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Proteins known as histones give structure to DNA, which coils around them like string on spools. But as is so often the case in biology, it turns out there is more to these structures than meets the eye.


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Reconstruction and 3D printing of the human embryo - University Hospital of Montpellier

Reconstruction and 3D printing of the human embryo - University Hospital of Montpellier | Bioscience News - GEG Tech top picks | Scoop.it
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This technology improves the microscopic observation of the embryo. It allows to analyze in 3D the human embryo generated in vitro in full compliance with ethical rules.

 

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Notch and Hippo Converge on Cdx2 to Specify the Trophectoderm Lineage in the Mouse Blastocyst: Developmental Cell

Notch and Hippo Converge on Cdx2 to Specify the Trophectoderm Lineage in the Mouse Blastocyst: Developmental Cell | Bioscience News - GEG Tech top picks | Scoop.it
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Artificial cells act like the real thing

Artificial cells act like the real thing | Bioscience News - GEG Tech top picks | Scoop.it
Scientists have created an artificial, network-like cell system that is capable of reproducing the dynamic behavior of protein synthesis. This achievement is not only likely to help gain a deeper understanding of basic biological processes, but it may, in the future, pave the way toward controlling the synthesis of both naturally-occurring and synthetic proteins for a host of uses.
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Pigs' hearts transplanted into baboon hosts remain viable more than a year

Pigs' hearts transplanted into baboon hosts remain viable more than a year | Bioscience News - GEG Tech top picks | Scoop.it
Investigators have successfully transplanted hearts from genetically engineered piglets into baboons' abdomens and had the hearts survive for more than one year, twice as long as previously reported. This was achieved by using genetically engineered porcine donors and a more focused immunosuppression regimen in the baboon recipients, according to a new study.
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Study: Testosterone In Men Increases Brain Response To Threats

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