Date: 19 Nov 2014
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Immunology Diagnosis
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El objetivo de este curso es el reciclaje y actualización de profesionales de la inmunología clínica en el campo de las Inmunodeficiencias.
Alfredo Corell's insight:
OBJETIVOS:
METODOLOGÍA DOCENTE:
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Basophil activation tests were more accurate than other tests in distinguishing between peanut allergy and tolerance in children, reducing the need for oral food challenges, according to recent study results.
Alfredo Corell's insight:
Santos AF. J Allergy Clin Immunol. 2014;doi:10.1016/j.jaci.2014.04.039.
July 28, 2014 Researchers studied 43 peanut-allergic (mean age, 5.5 years; 74.4% males), 36 peanut-sensitized but tolerant (mean age, 4 years; 63.9% males) and 25 non-peanut-sensitized nonallergic children (mean age, 5 years; 72% males) using skin prick test (SPT) and specific IgE (sIgE) to peanut. “BAT [basophil activation test] was performed using flow cytometry, and its diagnostic performance was evaluated in relation to allergy vs. tolerance to peanut and validated in an independent population (n=65),” the researchers wrote. There was a peanut dose-dependent upregulation of CD63 and CD203c in peanut-allergic children, based on BAT. Non-peanut-sensitized nonallergic and peanut-sensitized children, however, showed no significant response (P<.001, both). There was 97% accuracy, 95% positive predictive value and 98% negative predictive value in the BAT optimal diagnostic cutoffs.
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In most cases, the autoantibodies are against the acetylcholine receptor (AChR). Recently, other targets have been described such as the MuSK protein (muscle-specific kinase) or the LRP4 (lipoprotein related protein 4).
Alfredo Corell's insight:
In most cases, the autoantibodies are against the acetylcholine receptor (AChR). Recently, other targets have been described such as the MuSK protein (muscle-specific kinase) or the LRP4 (lipoprotein related protein 4). Link to the Journal Paper: http://www.sciencedirect.com/science/article/pii/S0896841114000055
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The important role of lab-diagnosis in disease discovery and follow-up
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Create flow cytometry settings that allow for standardized consistent fluorescence intensity target values.
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Guidelines and steps to standarize Flow cytometry.
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Upon selecting an image, you are taken to a new screen that offers one question—diagnosis, presenting symptoms, etc.—and five answers.
Alfredo Corell's insight:
The app randomly selects various dermatologic, radiologic and other pictures from the weekly published NEJM. The image is accompanied in the app with a multiple choice question, usually asking for diagnosis or presenting symptoms.
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Learn about training programs and career tracks for clinical laboratory immunologists--key contributors to the diagnosis and management of patients with immune-mediated conditions.
Alfredo Corell's insight:
Anne E. Tebo, PhD, Barbara Detrick, PhD, Robert G. Hamilton, PhD, Aaruni Khanolkar, MBBS, PhD, Maurice R. G. O'Gorman, PhD, John L. Schmitz, PhD, Roshini S. Abraham, PhD DisclosuresAm J Clin Pathol. 2014;142(4):437-444. Objectives Clinical laboratory immunology affects practically every aspect of medicine. Accordingly, appropriately trained, board-certified clinical laboratory immunologists are key contributors to the diagnosis and management of patients with various immune-mediated conditions. This review highlights the availability of postdoctoral level training programs for clinical laboratory immunology and identifies possible career tracks. Methods Fundamental elements for doctoral level clinical laboratory immunologists are identified and the critical components of diagnostic immunology training as well as career opportunities in and out of academia are described. Results Relative to other disciplines in laboratory medicine, little emphasis has been given to clinical laboratory immunology in medical, graduate, and postgraduate training. Formal postgraduate fellowship programs and board certification examinations are available, yet there remains a significant lack of awareness in the medical education community about the value and necessity of training in this field. Conclusions It is anticipated that sharing this knowledge will increase awareness of the discipline of clinical laboratory immunology at the postdoctoral level with implications for the practice of laboratory medicine. Link to the Journal: http://ajcp.ascpjournals.org/content/142/4/437.abstract
Gilbert C FAURE's curator insight,
November 9, 2014 2:42 AM
did not open where I was, Thks! a major challenge for the future not well understood by supporters of exclusive laboratory automation
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New diagnostic procedure helps differentiate psoriasis from eczema
Alfredo Corell's insight:
Other comment on the health press: http://www.helmholtz-muenchen.de/en/news/latest-news/press-information-news/article/24557/index.html The research paper: http://stm.sciencemag.org/content/6/244/244ra90
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La Sociedad Española de Alergología e Inmunología Clínica (SEAIC) ha defendido este jueves el empleo del diagnóstico molecular como complemento a las pruebas...
Alfredo Corell's insight:
La confianza en la coste-eficiencia de esta prueba de detección consistente en un análisis de sangre la razona el experto en un estudio realizado en la Comunidad de Madrid y publicado en la revista 'Allergy'. En él, ha confirmado que supone un ahorro del gasto y generar información "no solo a la ora de elegir una vacuna u otra, sino que predice un poco cual va a ser la evolución del paciente". Por ello, sostiene que debe realizarse en "prácticamente todo tipo de pacientes", como los alérgicos a alimentos, pólenes, ácaros o epitelios de animales. A pesar de que existen casos de pacientes muy sencillos y que "se solventan con pruebas cutáneas", advierte de que "cada vez hay más pacientes que aparentemente son sensibles a muchas cosas, y que son los que se benefician".
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By Anna Azvolinsky, LiveScience Contributor Published: 12/04/2013 03:25 PM EST on LiveScience A sensitive new DNA test can predict how long ovarian cancer patients will survive, and guide personalized treatment decisions, according to new research.
Alfredo Corell's insight:
The technology, called QuanTILfy, counts the number of cells called tumor-infiltrating lymphocytes (TILs) in a cancer patient's tumor biopsy. Cancer patientswith more of these cells in their tumor tend to have better outcomes, previous studies in ovarian, colorectal and other cancers have shown. A divulgative new in spanish: http://www.elmundo.es/salud/2013/12/09/52a0d4010ab740f5568b458f.html ;
The original publication Sci Transl Med 4 December 2013:
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Programa de Garantía Externa de Calidad para Laboratorios de Inmunología Diagnóstica
Alfredo Corell's insight:
Mínimo precio - Gran calidad Comienzo inminente el 10 de junio de 2013 plazas disponibles
Instrucciones de inscripción: http://www.geclidsei.uva.es/mod/resource/view.php?id=2773
Alfredo Corell's comment,
June 9, 2013 2:37 PM
No puedes adjuntar una copia de tu resguardo de pago con el boletín de inscripción. Pero se lo puedes mandar a nuestros administrativos en geclid-sei@ioba.med.uva.es
Alfredo Corell's curator insight,
June 9, 2013 2:55 PM
Programa de los cursos y metodologia docente: http://www.geclidsei.uva.es/mod/resource/view.php?id=3165
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Leukemia is one of the leading journals in hematology and oncology. It is published monthly and covers all aspects of the research and treatment of leukemia and allied diseases.
Alfredo Corell's insight:
It is a european consortium working in an useful and important homogeneization protocols for diagnosis of haematologic malignancies in Europe. The history stars fabulous. Then, when your read the papers and see that some very popular and good flow cytometers aren't there (as the Galios, for example), and when you see also an important byass in the recomended providers for fluorescent monoclonals... it doesn't seem so fabulous.
Alfredo Corell's curator insight,
January 7, 2013 7:07 AM
It is a european consortium working in an useful and important homogeneization protocols for diagnosis of haematologic malignancies in Europe. The history starts fabulous. Then, when your read the papers and see that some very popular and good flow cytometers aren't there (as the Galios, for example), and when you see also an important byass in the recomended providers for fluorescent monoclonals... it doesn't seem so fabulous.
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( http://www.abnova.com ) - Immunofluorescence is a technique to visualize a specific protein or antigen in cells or tissue sections by binding a specific an...
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Rheumatoid Arthritis (RA) is an autoimmune destructive joint disease, characterized by the presence of rheumatoid factor and anti-citrullinated peptide antibodies. Anti-citrullinated peptide antibodies were recently defined as RA criterion with sensitivity and specificity of 50–80 and 75–95 %, respectively. However, in the general population, the predictive value of anti-citrullinated peptide antibodies is yet to be determined. Herein, we aim to determine the predictive value of anti-citrullinated peptide antibodies in real life as well as clinical and serological factors related to this value. Retrospective cross-sectional study of consecutive samples evaluated for anti-citrullinated peptide antibodies in a referral autoimmune laboratory. Demographic and clinical parameters at the time the sample was drawn were collected. During November 2011 through December 2013, a total of 215 anti-citrullinated peptide antibody tests were performed in our laboratory. Data were available for 140 samples of which only 28 samples were positive for anti-citrullinated peptide antibodies. Of the 140 patients tested, 18 were diagnosed with RA, of which 12 were positive and 6 were negative for anti-citrullinated peptide antibody test. Thus, in this cohort, anti-citrullinated peptide antibodies were positive in 20 % of samples with a positive predictive value (PPV) of 43 % and a negative predictive value of 95 %. In real life, only 20 % of anti-citrullinated peptide antibody tests referred to a tertiary center where found to be positive. The negative predictive value of this test is very high and may support the common use of anti-citrullinated peptide antibody test as an exclusion criterion in the process of evaluating a patient with rheumatic disease.
Download the pdf: http://link.springer.com/content/pdf/10.1007%2Fs12026-014-8566-4.pdf