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New method of mass-producing high-quality DNA molecules | KurzweilAI

New method of mass-producing high-quality DNA molecules | KurzweilAI | Longevity science | Scoop.it

A new method of manufacturing short, single-stranded DNA molecules can solve many of the problems associated with current production methods.

 

The new method can be of value to development of drugs consisting of DNA fragments and to DNA nanotechnology research.

 

The novel technique for manufacturing short, single-stranded DNA molecules — or oligonucleotides — has been developed by researchers at Karolinska Institute in Sweden and Harvard University.

 

 

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New Biomarker May Allow Earlier Diagnosis of Mesothelioma

"Researchers have shown that the protein fibulin-3 may be able to distinguish patients with mesothelioma from people with similar conditions and from healthy individuals. Although preliminary, the results suggest that this protein may be a promising new biomarker for diagnosing the disease and possibly informing prognosis. The study was published October 11 in the New England Journal of Medicine.

 

Pleural mesothelioma, a disease of the tissue that lines the chest cavity and covers the lungs (the pleura), is an aggressive cancer often associated with asbestos exposure. Patients diagnosed with this disease have a median survival of 1 year.

 

Diagnosing mesothelioma early, when treatment may be most effective, is difficult because of its long latency period and the lack of reliable methods to detect the disease in its early stages. A protein called soluble mesothelin-related protein is the best-studied biomarker for mesothelioma, but the test for it has low sensitivity, meaning that it fails to detect mesothelioma in some people who have the disease.."


Via Brian Shields
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New clot drug for heart patients

New clot drug for heart patients | Longevity science | Scoop.it

Hundreds of thousands of heart patients could benefit from new blood thinning drugs to cut their risk of stroke.

 

The existing (and popular) blood thinning medications coumadin and warfarin have a number of side effects and require frequent monitoring and often dietary adjustments to maintain proper levels.

 

Alternatives to these drugs, although bound to have their own side effects, could help many patients who require blood thinners to reduce stroke risk.

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Do statins drain your energy?

There is a large population that take 'statin drugs' to lower cholesterol.

 

These drugs are very effective, but can result in muscle pain and fatigue. Why? The drugs deplete the body's natural reserves of CoEnzyme Q10, which is involved in energy production at the cellular level.

 

Fortunately, supplementing with the enzyme can help restore the blood levels and counterract the side effects. But few doctors mention this when they prescribe the drugs.

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Drug Helps Immune System Fight Cancer

Drug Helps Immune System Fight Cancer | Longevity science | Scoop.it

One of the great frustrations for researchers in the war on cancer is that the body’s own defense system does not do a better job fighting the disease. Tumors, it turns out, have a molecular shield that repels attacks from the immune system.

 

Now, a new study says, an experimental drug is showing promise in disabling that shield...

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Bypassing the blood-brain barrier with MRI and ultrasound | KurzweilAI

Bypassing the blood-brain barrier with MRI and ultrasound | KurzweilAI | Longevity science | Scoop.it

In an experiment that may help develop new ways to treat brain diseases like Alzheimer's and cancer, researchers used MRI, ultrasounds and microbubbles to guide drugs.

 

 

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Supplements For Depression & Anxiety - Nutraceuticals World

Supplements For Depression & Anxiety - Nutraceuticals World | Longevity science | Scoop.it

Many people now use pharmaceuticals to help manage their moods. Anxiety is commonplace in a world where everything moves quickly and multi-tasking is a necessity.

 

Are there other options?

 

Possibly. New research lends credence to the use of two natural supplements for depression and anxiety.

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Rice-Cell Cocktail Tough on Cancer Cells, Nice to Normal Cells

Rice-Cell Cocktail Tough on Cancer Cells, Nice to Normal Cells | Longevity science | Scoop.it

Juice from rice cells can knock out two kinds of human cancer cells as well or better than the potent anti-cancer drug Taxol, a Michigan Technological University scientist has discovered in laboratory tests. Plus, it does something Taxol can’t do: it plays nice with normal cells.

 

 

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Delivering drugs via nanoparticles to target mitochondria | KurzweilAI

Delivering drugs via nanoparticles to target mitochondria | KurzweilAI | Longevity science | Scoop.it

Researchers at the University of Georgia have refined the nanoparticle drug delivery process further by using nanoparticles to deliver drugs to a specific organelle within cells.

 

By targeting mitochondria, “the powerhouse of cells,” the researchers increased the effectiveness of mitochondria-acting therapeutics used to treat cancer, Alzheimer’s disease and obesity in studies conducted with cultured cells.

 

 

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Virtual safety panel predicts drugs' side effects

Virtual safety panel predicts drugs' side effects | Longevity science | Scoop.it

A team of scientists from the UCSF School of Pharmacy, Novartis Institutes for Biomedical Research (NIBR) and SeaChange Pharmaceuticals has developed a set of computer models that can predict negative side effects associated with existing drugs. By speeding up the process and increasing accuracy, the software could potentially save billions in research and decrease the number of animals used in toxicity tests.

 

The model, based on UCSF’s “similarity ensemble approach” (SEA), uses the similarities between the shape of each drug and thousands of other compounds to predict possible side effects. The theory behind SEA technology is that proteins can be related by their pharmacology, and these network relationships can be explored to discover new targets for established drugs.

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Anti-Inflammatory Drug with a New Benefit to Glucose

In a modern-day clinical trial of a medicine belonging to one of the world's oldest classes of drugs, researchers have found that a drug related to aspirin and salicylate, which was first used by ancient Egyptians and Greeks to ease pain caused by inflammation, also has glucose-lowering properties and may be a potential treatment for people with type 2 diabetes, according to results presented at the American Diabetes Association's 72nd Scientific Sessions(R).

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First Stem Cell-Based Therapy Gets Approved – In Canada | Singularity Hub

First Stem Cell-Based Therapy Gets Approved – In Canada | Singularity Hub | Longevity science | Scoop.it

A medical treatment that uses stem cells derived from bone marrow has just been approved in Canada.

 

The drug, Prochymal, has already been used to treat children for a type of immune disease arising during bone marrow transplantation.

 

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Analysis: India cancer ruling opens door for cheaper drugs

Analysis: India cancer ruling opens door for cheaper drugs | Longevity science | Scoop.it

The Indian Patent Office ruled that a local generic drug maker can make and sell a knock-off of drug giant Bayer's exclusive Nexavar,  a cancer drug.

 

This is only the second time in history that a nation has issued a compulsory license for cancer medication.

 

Experts believe that this may threaten the big business of global pharmaceutical firms...

Ray and Terry's 's comment, March 19, 2012 4:21 PM
Does this ruling matter to the poorest patients?
http://www.reuters.com/article/2012/03/18/us-india-drugs-cancer-idUSBRE82H01A20120318