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Induced "pacemaker" heart cells could take the place of man-made pacemakers

Induced "pacemaker" heart cells could take the place of man-made pacemakers | Longevity science | Scoop.it

Scientists at the Cedars-Sinai Heart Institute have successfully reprogrammed ordinary heart cells to become exact replicas of so-called “pacemaker” heart cells. Such replica cells could conceivably one day be used instead of electronic pacemakers, in patients with heart disease.

 

Also known as SAN cells, pacemaker cells constitute about 10,000 of the human heart’s approximately 10 billion total cells. They generate coordinated electrical impulses that result in rhythmic contractions of the heart muscle – in other words, they allow the heart to beat. If something goes wrong with them, the implantation of an electronic pacemaker is often required ... for now.

 

 

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How to create beating heart muscle cells | KurzweilAI

How to create beating heart muscle cells | KurzweilAI | Longevity science | Scoop.it

UCLA stem-cell researchers have found for the first time a surprising and unexpected plasticity in the embryonic endothelium, the place where blood stem cells are made in early development.

 

They found that the lack of one transcription factor, a type of gene that controls cell fate (by regulating other genes), allows the precursors that normally generate blood stem and progenitor cells in blood-forming tissues to become something very unexpected — beating cardiomyocytes, or heart muscle cells.

 

 

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