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Researchers at the University of Georgia have refined the nanoparticle drug delivery process further by using nanoparticles to deliver drugs to a specific organelle within cells.
By targeting mitochondria, “the powerhouse of cells,” the researchers increased the effectiveness of mitochondria-acting therapeutics used to treat cancer, Alzheimer’s disease and obesity in studies conducted with cultured cells.
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MIT researchers have developed RNA-delivering nanoparticles that allow for rapid screening of new drug targets in mice.
By sequencing cancer-cell genomes, scientists have discovered vast numbers of genes that are mutated, deleted or copied in cancer cells. This treasure trove is a boon for researchers seeking new drug targets, but it is nearly impossible to test them all in a timely fashion.
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"Researchers at Harvard-affiliated McLean Hospital have developed a new category of non-toxic, protein-based green nanoparticles that can non-invasively cross the blood brain barrier and transport various types of drugs."
The particles "crossed and/or bypassed the blood-brain barrier without enhancers or modifications, unlike other nanoparticles. These findings open the door to exploring..."
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One result of the side effects of cancer treatments is that patients often can’t tolerate or survive a combination of different drugs at the same time — which can limit a doctor’s ability to knock out the disease.
The head of a Boston-area biotech called Cerulean Therapeutics thinks the solution is nanoparticle-delivered drugs, which have fewer and less severe side effects. They could make it easier for doctors to mount a multipronged attack on tumors and kill the cells before they can develop a resistance to any one compound.
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Researchers have now reported that the use of quantum dots - tiny luminescent crystals that can be used to monitor disease at a cellular level - appears to be safe in primates over a one-year period.
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