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Researchers at the University of Michigan Life Sciences Institute have identified a genetic program that promotes longevity of roundworms (nematodes) in cold environments — and this genetic program also exists in warm-blooded animals, including humans.
“This raises the intriguing possibility that exposure to cold air — or pharmacological stimulation of the cold-sensitive genetic program — may promote longevity in mammals,” said Shawn Xu, LSI faculty member and the Bernard W. Agranoff Collegiate Professor in the Life Sciences at the U-M Medical School.
Scientists had long assumed that animals live longer in cold environments because of a passive thermodynamic process, reasoning that low temperatures reduce the rate of chemical reactions and thereby slow the rate of aging.
