Disruption in circadian rhythms can lead to higher instances of weight gain and diabetes.
Humans have not evolved to efficiently work the night shift.
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Longevity science
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New research supports a largely unrecognized culprit in circadian rhythm disturbances: the gradual yellowing of the lens and the narrowing of the pupil that come with age.
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http://www.kurzweilai.net/disruption-of-biological-clocks-causes-neurodegeneration-early-death