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Upregulation of extrinsic apoptotic pathway i... [J Cell Biochem. 2013] - PubMed - NCBI

"Results showed that curcumin induces growth arrest and apoptosis in pancreatic cancer cell lines. Its effect was more obvious on the highly COX-2 expressing cell line..."

 

 

Biotivia Longevity's curator insight, June 26, 2013 9:24 PM

Curcumin features a lot in research studies. Men with prostate concerns could look into adding curcumin to their diet. Curcumin is an active ingredient of the spice turmeric.

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Matching Tumors With The Optimal Cancer Drugs - Science 2.0

Matching Tumors With The Optimal Cancer Drugs - Science 2.0 | Longevity science | Scoop.it
Matching Tumors With The Optimal Cancer Drugs
Science 2.0
The main driver of pancreatic cancer, a mutation in a gene called KRAS, has proven difficult to target with treatments.

Via Brian Shields
Brian Shields's curator insight, February 7, 2013 11:18 AM

Very Powereful Quote and an important one for clinicians to understand, " We have a small but effective inventory of 'druggable' mutations that we know play a role in cancer"

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Dietary antioxidants may help slash pancreatic cancer risk: EPIC data

Increasing dietary intake of certain antioxidants could help to cut the risk of developing pancreatic cancer by up to two thirds, according to new research.
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Pluripotent cells from pancreatic cancer cells first human model of cancer's progression

Pluripotent cells from pancreatic cancer cells first human model of cancer's progression | Longevity science | Scoop.it

University of Pennsylvania scientists have used stem-cell technology to create a research cell line from a patient with advanced pancreatic ductal adenocarcinoma(PDAC).

 

This first-of-its-kind human-cell model of pancreatic cancer progression was published this week in Cell Reports from the lab of Ken Zaret, PhD, professor of Cell and Developmental Biology.

 

"It is the first example using induced pluripotent stem [iPS] cells to model cancer progression directly from a solid tumor, and the first human cell line that can model pancreatic cancer progression from early to invasive stages," says Zaret, also the associate director of the Penn Institute for Regenerative Medicine.

 

 

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Drug From Chinese ‘Thunder God Vine’ Kills Pancreas Tumors in Mice

Drug From Chinese ‘Thunder God Vine’ Kills Pancreas Tumors in Mice | Longevity science | Scoop.it

A drug made from a plant known as “thunder god vine,” or lei gong teng, that has been used in traditional Chinese medicine, wiped out pancreatic tumors in mice, researchers said, and may soon be tested in humans.

 

Mice treated with the compound showed no signs of tumors after 40 days or after discontinuing the treatment, according to researchers at the University of Minnesota’s Masonic Cancer Center. The research, funded by the university and the National Institutes of Health. was published today in the journal Science Translational Medicine.

 

“This drug is just unbelievably potent in killing tumor cells,” said Ashok Saluja, vice chairman of research at the center and the study’s leader, said in a telephone interview. “You could see that every day you looked at those mice, the tumor was decreasing and decreasing, and then just gone.”

 

The plant, also known as Tripterygium wilfordii, contains triptolide, which earlier studies have shown can cause cancer cells to die. In traditional Chinese medicine, the plant is used as a treatment for rheumatoid arthritis. While the researchers hope to start human trials in six months, Saluja said it’s still a long leap from mice to people.


Via Dr. Stefan Gruenwald
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'Promising' pancreas cancer drug

'Promising' pancreas cancer drug | Longevity science | Scoop.it
Scientists report promising results for an experimental pancreatic cancer drug treatment.

 

More than 80% of patients with pancreatic cancer die within a year of diagnosis. This sad prognosis has prompted Cancer Research UK to allocate more funds to related treatments. Pancreatic cancer is the fifth most common cause of death by cancer in the UK.

 

In initial trials, the new drug has been seen to shrink tumors. Next up-- clinical trials, which will involve about 60 patients.

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