NeuroImmunology
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Scooped by Gilbert C FAURE from Multiple sclerosis New Drugs Review
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Seeking balance: Potentiation and inhibition of multiple sclerosis autoimmune responses by IL-6 and IL-10

Highlights

 

MS B cells secrete more IL-6 and less IL-10 than B cells from healthy donors.

B cell depletion therapy, which ameliorates disease, diminishes IL-6 levels.

GA therapy temporarily restores immune regulation, as detected by IL-6 levels.

IL-10 secreted by T regulatory cells and monocytes contribute to immune regulation.

Agents that enhance IL-10 and immunoregulation are of therapeutic benefit in MS.


Via Krishan Maggon
Krishan Maggon 's curator insight, May 8, 2015 8:32 AM

Cytokine

Volume 73, Issue 2, June 2015, Pages 236–244

Review Article Seeking balance: Potentiation and inhibition of multiple sclerosis autoimmune responses by IL-6 and IL-10Sara J. Irelanda, 1, 3, , Nancy L. Monsona, 2, 3, , , Laurie S. Davisb, , 3,    Show moreChoose an option to locate/access this article:Check if you have access through your login credentials or your institutionCheck access  Purchase $35.95  doi:10.1016/j.cyto.2015.01.009

Scooped by Gilbert C FAURE from Alzheimer's Disease R&D Review
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STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior : Scientific Reports : Nature Publishing Group

STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior : Scientific Reports : Nature Publishing Group | NeuroImmunology | Scoop.it
Experimental evidence suggests a role for the immune system in the pathophysiology of depression.

Via Krishan Maggon
Krishan Maggon 's curator insight, March 13, 2015 8:45 AM

SCIENTIFIC REPORTS | ARTICLE OPEN

PrintShare/bookmark STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behaviorEryan Kong,Sonja Sucic,Francisco J. Monje,Giorgia Savalli,Weifei Diao,Deeba Khan,Marianne Ronovsky,Maureen Cabatic,Florian Koban,Michael Freissmuth& Daniela D. PollakAffiliationsContributionsCorresponding authorScientific Reports 5, Article number: 9009 doi:10.1038/srep09009Received 23 September 2014 Accepted 11 February 2015 Published 11 March 2015