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Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS). Neither the antigenic target(s) nor the cell population(s) responsible for CNS tissue destruction in MS have been fully defined. Via Krishan Maggon 
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Dysregulation of the complement system is evident in many CNS diseases but mechanisms regulating complement activation in the CNS remain unclear. Via Krishan Maggon
Krishan Maggon 's curator insight,
April 7, 2015 2:35 AM
Citation: Aeinehband S, Lindblom RPF, Al Nimer F, Vijayaraghavan S, Sandholm K, et al. (2015) Complement Component C3 and Butyrylcholinesterase Activity Are Associated with Neurodegeneration and Clinical Disability in Multiple Sclerosis. PLoS ONE 10(4): e0122048. doi:10.1371/journal.pone.0122048
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PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world. Via Krishan Maggon
Krishan Maggon 's curator insight,
November 21, 2014 4:03 AM
Uptake and Presentation of Myelin Basic Protein by Normal Human B CellsMarie Klinge Brimnes, Bjarke Endel Hansen, Leif Kofoed Nielsen, Morten Hanefeld Dziegiel, Claus Henrik Nielsen mail Published: November 17, 2014DOI: 10.1371/journal.pone.0113388
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Sphingolipids are important in many brain functions but their role in Alzheimer’s disease (AD) is not completely defined. A major limit is availability of fresh brain tissue with defined AD pathology. Via Krishan Maggon
Krishan Maggon 's curator insight,
May 5, 2015 5:50 AM
Citation: Fonteh AN, Ormseth C, Chiang J, Cipolla M, Arakaki X, et al. (2015) Sphingolipid Metabolism Correlates with Cerebrospinal Fluid Beta Amyloid Levels in Alzheimer’s Disease. PLoS ONE 10(5): e0125597. doi:10.1371/journal.pone.0125597
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Objective Effect of fingolimod in multiple sclerosis (MS) is thought to involve the prevention of lymphocyte egress from lymphoid tissues, thereby reducing autoaggressive lymphocyte infiltration into the central nervous system across blood-brain... Via Krishan Maggon
Krishan Maggon 's curator insight,
March 17, 2015 7:04 AM
Citation: Nishihara H, Shimizu F, Sano Y, Takeshita Y, Maeda T, et al. (2015) Fingolimod Prevents Blood-Brain Barrier Disruption Induced by the Sera from Patients with Multiple Sclerosis. PLoS ONE 10(3): e0121488. doi:10.1371/journal.pone.0121488 |
Citation: Wuest SC, Mexhitaj I, Chai NR, Romm E, Scheffel J, Xu B, et al. (2014) A Complex Role of Herpes Viruses in the Disease Process of Multiple Sclerosis. PLoS ONE 9(8): e105434. doi:10.1371/journal.pone.0105434
HPV in MS? wow....