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Highlights
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MS B cells secrete more IL-6 and less IL-10 than B cells from healthy donors.
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B cell depletion therapy, which ameliorates disease, diminishes IL-6 levels.
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GA therapy temporarily restores immune regulation, as detected by IL-6 levels.
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IL-10 secreted by T regulatory cells and monocytes contribute to immune regulation.
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Agents that enhance IL-10 and immunoregulation are of therapeutic benefit in MS.
Via Krishan Maggon
Cytokine
Volume 73, Issue 2, June 2015, Pages 236–244
Review Article Seeking balance: Potentiation and inhibition of multiple sclerosis autoimmune responses by IL-6 and IL-10Sara J. Irelanda, 1, 3, , Nancy L. Monsona, 2, 3, , , Laurie S. Davisb, , 3, Show moreChoose an option to locate/access this article:Check if you have access through your login credentials or your institutionCheck access Purchase $35.95 doi:10.1016/j.cyto.2015.01.009