Dysregulation of the complement system is evident in many CNS diseases but mechanisms regulating complement activation in the CNS remain unclear.
Via Krishan Maggon
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Krishan Maggon 's curator insight,
March 3, 2015 11:55 AM
Beta amyloid was detected in younger brains 20 yr of age.
Brain Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer’s disease Alaina Baker-Nigh , Shahrooz Vahedi , Elena Goetz Davis , Sandra Weintraub , Eileen H. Bigio , William L. Klein , Changiz GeulaDOI: http://dx.doi.org/10.1093/brain/awv024 First published online: 2 March 2015
Krishan Maggon 's curator insight,
February 19, 2015 3:26 AM
Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s diseaseElizabeta Gjoneska,Andreas R. Pfenning,Hansruedi Mathys,Gerald Quon,Anshul Kundaje,Li-Huei Tsai& Manolis KellisAffiliationsContributionsCorresponding authorsNature 518, 365–369 (19 February 2015) doi:10.1038/nature14252Received 07 January 2014 Accepted 22 January 2015 Published online 18 February 2015
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Krishan Maggon 's curator insight,
March 18, 2015 4:11 AM
Citation: Aubry S, Shin W, Crary JF, Lefort R, Qureshi YH, et al. (2015) Assembly and Interrogation of Alzheimer’s Disease Genetic Networks Reveal Novel Regulators of Progression. PLoS ONE 10(3): e0120352. doi:10.1371/journal.pone.0120352
Krishan Maggon 's curator insight,
March 2, 2015 2:10 AM
NATURE IMMUNOLOGY | REVIEW Innate immunity in Alzheimer's diseaseMichael T Heneka,Douglas T Golenbock& Eicke LatzAffiliationsCorresponding authorNature Immunology 16, 229–236 (2015) doi:10.1038/ni.3102Received 03 December 2014 Accepted 13 January 2015 Published online 17 February 2015
Krishan Maggon 's curator insight,
January 11, 2015 4:29 AM
Pharmacological Reports
Volume 67, Issue 2, April 2015, Pages 195–203 Review article A review on Alzheimer's disease pathophysiology and its management: an updateAnil Kumar, , , Arti Singh, Ekavali doi:10.1016/j.pharep.2014.09.004 |
Citation: Aeinehband S, Lindblom RPF, Al Nimer F, Vijayaraghavan S, Sandholm K, et al. (2015) Complement Component C3 and Butyrylcholinesterase Activity Are Associated with Neurodegeneration and Clinical Disability in Multiple Sclerosis. PLoS ONE 10(4): e0122048. doi:10.1371/journal.pone.0122048