Scooped by Julio Retamales |
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Authors: Jinpeng Li, Xingbei Liu, Shumin Chang, Wei Chu, Jingchen Lin, Hui Zhou, Zhuoran Hu, Mancang Zhang, Mingming Xin, Yingyin Yao, Weilong Guo, Xiaodong Xie, Huiru Peng, Zhongfu Ni, Qixin Sun, Yu Long and Zhaorong Hu.
Science Advances (2024)
One-sentence summary: TaNHX2 exerts flexible role in stomatal response under drought stress via modulating GABA accumulation in wheat.
Abstract: Drought is a major global challenge in agriculture that decreases crop production. γ-Aminobutyric acid (GABA) interfaces with drought stress in plants; however, a mechanistic understanding of the interaction between GABA accumulation and drought response remains to be established. Here we showed the potassium/proton exchanger TaNHX2 functions as a positive regulator in drought resistance in wheat by mediating cross-talk between the stomatal aperture and GABA accumulation. TaNHX2 interacted with glutamate decarboxylase TaGAD1, a key enzyme that synthesizes GABA from glutamate. Furthermore, TaNHX2 targeted the C-terminal auto-inhibitory domain of TaGAD1, enhanced its activity, and promoted GABA accumulation under drought stress. Consistent with this, the tanhx2 and tagad1 mutants showed reduced drought tolerance, and transgenic wheat with enhanced TaNHX2 expression had a yield advantage under water deficit without growth penalty. These results shed light on the plant stomatal movement mechanism under drought stress and the TaNHX2-TaGAD1 module may be harnessed for amelioration of negative environmental effects in wheat as well as other crops."
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Relevant finding!
Text of figure above: "Fig. 8. A proposed model that TaNHX2 interacts with TaGAD1 to promote drought resistance in wheat. The tonoplast-localized cation exchanger TaNHX2 contributes to drought resistance transduced by interacting with the C-terminal auto-inhibitory domain of TaGAD1, up-regulates TaGAD1 activity, and promotes GABA accumulation under drought stress. GABA has been found to reduce stomatal opening and increase WUE by negative modulation activity of a guard cell tonoplast-localized anion transporter ALMT9 (42). TaNHX2 promotes stomatal closure by enhancing GABA accumulation and signaling pathway upon drought stress and is essential for drought resistance in wheat."
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