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Virus World

Virus World provides a daily blog of the latest news in the Virology field and the COVID-19 pandemic. News on new antiviral drugs, vaccines, diagnostic tests, viral outbreaks, novel viruses and milestone discoveries are curated by expert virologists. Highlighted news include trending and most cited scientific articles in these fields with links to the original publications. Stay up-to-date with the most exciting discoveries in the virus world and the last therapies for COVID-19 without spending hours browsing news and scientific publications. Additional comments by experts on the topics are available in Linkedin (https://www.linkedin.com/in/juanlama/detail/recent-activity/)
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A single Dose of ChAdOx1 Chik Vaccine Induces Neutralizing Antibodies Against Four Chikungunya Virus Lineages in a Phase 1 Clinical Trial

A single Dose of ChAdOx1 Chik Vaccine Induces Neutralizing Antibodies Against Four Chikungunya Virus Lineages in a Phase 1 Clinical Trial | Virus World | Scoop.it
From www.nature.com - August 4, 2021 11:35 AM

Chikungunya virus (CHIKV) is a reemerging mosquito-borne virus that causes swift outbreaks. Major concerns are the persistent and disabling polyarthralgia in infected individuals. Here we present the results from a first-in-human trial of the candidate simian adenovirus vectored vaccine ChAdOx1 Chik, expressing the CHIKV full-length structural polyprotein (Capsid, E3, E2, 6k and E1). 24 adult healthy volunteers aged 18–50 years, were recruited in a dose escalation, open-label, nonrandomized and uncontrolled phase 1 trial (registry NCT03590392). Participants received a single intramuscular injection of ChAdOx1 Chik at one of the three preestablished dosages and were followed-up for 6 months. The primary objective was to assess safety and tolerability of ChAdOx1 Chik.

 

The secondary objective was to assess the humoral and cellular immunogenicity. ChAdOx1 Chik was safe at all doses tested with no serious adverse reactions reported. The vast majority of solicited adverse events were mild or moderate, and self-limiting in nature. A single dose induced IgG and T-cell responses against the CHIKV structural antigens. Broadly neutralizing antibodies against the four CHIKV lineages were found in all participants and as early as 2 weeks after vaccination. In summary, ChAdOx1 Chik showed excellent safety, tolerability and 100% PRNT50 seroconversion after a single dose. Chikungunya virus (CHIKV) is a reemerging mosquito-borne virus that has caused outbreaks in various regions of the world. Here the authors present safety and immunogenicity data from a phase 1 trial with the simian adenovirus vectored vaccine ChAdOx1 Chik, showing induction of neutralizing antibodies to four CHIKV lineages.

 

Published in Nat. Communications (July 30, 2021):

https://doi.org/10.1038/s41467-021-24906-y

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Malaria Vaccine Hailed as Potential Breakthrough

Malaria Vaccine Hailed as Potential Breakthrough | Virus World | Scoop.it
From www.bbc.com - April 25, 2021 10:54 AM

A malaria vaccine has proved to be 77% effective in early trials and could be a major breakthrough against the disease, says the University of Oxford team behind it. Malaria kills more than 400,000 people a year, mostly children in sub-Saharan Africa. But despite many vaccines being trialled over the years, this is the first to meet the required target. The researchers say this vaccine could have a major public health impact. When trialled in 450 children in Burkina Faso, the vaccine was found to be safe, and showed "high-level efficacy" over 12 months of follow-up. Larger trials in nearly 5,000 children between the ages of five months and three years will now be carried out across four African countries to confirm the findings. Malaria is a life-threatening disease caused by parasites that are transmitted to people through mosquito bites. Although preventable and curable, the World Health Organization estimates there were 229 million cases worldwide in 2019 and 409,000 deaths. The illness starts with symptoms such as fever, headaches and chills and, without treatment, can progress quickly to severe illness and often death.

 

'Major health impact'

 

Study author Adrian Hill, director of the Jenner Institute and professor of vaccinology at the University of Oxford, said he believed the vaccine was the first to reach the World Health Organization's goal of at least 75% efficacy. The most effective malaria vaccine to date had only shown 55% efficacy in trials on African children.  The trials of this malaria vaccine started in 2019, long before coronavirus appeared - and the Oxford team developed its Covid vaccine (with AstraZeneca) on the strength of its research into malaria, Prof Hill said. A malaria vaccine has taken much longer to come to fruition because there are thousands of genes in malaria compared to around a dozen in coronavirus, and a very high immune response is needed to fight off the disease. "That's a real technical challenge," Prof Hill said. "The vast majority of vaccines haven't worked because it's very difficult." However, he said the trial results meant the vaccine was "very deployable" and "has the potential to have a major public health impact".

 

'Tool for saving lives'

 

In a pre-print study with The Lancet, the research team - from Oxford, Nanoro in Burkina Faso and the US - reported the trial results of R21/Matrix-M, after testing a low and high dose of the vaccine in children, between May and August, before peak malaria season. The vaccine showed 77% efficacy in the higher-dose group and 71% in the lower-dose group.  Halidou Tinto, professor in parasitology and the principal trial investigator at the Clinical Research Unit of Nanoro, Burkina Faso, said the results were "very exciting" and showed "unprecedented efficacy levels". "We look forward to the upcoming 'phase III' trial to demonstrate large-scale safety and efficacy data for a vaccine that is greatly needed in this region." In Africa, there have been more deaths from malaria than from coronavirus in the past year. The Serum Institute of India, which has manufactured the vaccine, says it is confident of delivering more than 200 million doses of the vaccine as soon as it is approved by regulators. Biotechnology company Novavax provided the adjuvant for the vaccine, an ingredient which is used to create a stronger immune response. Malaria is one of the leading causes of childhood mortality in Africa and Prof Charlemagne Ouédraogo, minister of health in Burkina Faso, said the new data showed that a new malaria vaccine could be licensed "in the coming years". "That would be an extremely important new tool for controlling malaria and saving many lives," he said.

 
Preprint available in The Lancet (April 20, 2021):
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