Virus World
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Virus World
Virus World provides a daily blog of the latest news in the Virology field and the COVID-19 pandemic. News on new antiviral drugs, vaccines, diagnostic tests, viral outbreaks, novel viruses and milestone discoveries are curated by expert virologists. Highlighted news include trending and most cited scientific articles in these fields with links to the original publications. Stay up-to-date with the most exciting discoveries in the virus world and the last therapies for COVID-19 without spending hours browsing news and scientific publications. Additional comments by experts on the topics are available in Linkedin (https://www.linkedin.com/in/juanlama/detail/recent-activity/)
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Polio Virus Detected in London Sewage Samples

Polio Virus Detected in London Sewage Samples | Virus World | Scoop.it

Health officials say parents should ensure their children have been vaccinated against the disease.  The virus that causes polio has been detected in a concerning number of sewage samples in London, health officials have said. The disease was common in the UK in the 1950s but was eliminated by 2003. The UK Health Security Agency (UKHSA) says it was probably imported to London by someone who was recently vaccinated overseas with a live form of the virus. It says the risk is low, but parents should ensure their children have been fully immunised against the disease. "Most of the UK population will be protected from vaccination in childhood, but in some communities with low vaccine coverage, individuals may remain at risk," said Dr Vanessa Saliba, consultant epidemiologist at UKHSA. An inactivated polio vaccine is used in the UK as part of the routine childhood programme. It is given to children three times before the age of one, and then again at three and 14 years of age.  Take-up of the first three doses is about 86% in London, well below target levels, with the rest of the UK over 92%. Health authorities have now declared a national incident and informed the World Health Organization (WHO) of the situation.

Sewage detection

Over the past four months, the UKHSA has found the polio virus in samples collected from the Beckton sewage works, which serves a population of four million in north and east London. Scientists believe the virus originated from someone who was immunised abroad with the live oral polio vaccine, which hasn't been used in the UK since 2004. That person then shed traces of the virus from their gut which were detected by the sewage sampling. In rare cases, that form of the virus can then be transmitted to others and mutate into what is known as "vaccine-derived" polio. Although weaker than the original or "wild" form of the disease, it can still cause serious illness, including paralysis, in people who are unvaccinated. A tiny number of samples of the polio virus are detected each year in sewage surveillance, but this is the first time that a cluster of genetically-linked samples has been found repeatedly over a period of months.  Health officials say this suggests there has been some spread between closely linked individuals in London. No actual cases of polio have been detected and there have been no reports of rare but serious symptoms in the UK. Health Secretary Sajid Javid told the BBC that he was not "particularly worried" about the detection of polio. He added that he had been reminded by the UK's Health and Security Agency that the UK has a high vaccination rate against the virus, with no cases since 2003. Jane Clegg, chief nurse for the NHS in London, said the health service would be contacting parents of children aged under five in London who are not up to date with their childhood jabs. "Parents can also check their child's vaccination status in their red book, and people should contact their GP practice to book a vaccination should they or their child not be fully up to date," she said.

Rare disease

Polio is a rare disease and is spread after a person does not wash their hands properly after using the toilet and then touches food or water consumed by others, or in rarer cases by coughing and sneezing. Most people don't have any symptoms and will fight off the virus without even realising they were infected. A small number will experience flu-like symptoms for up to three weeks. In a very small number of cases, thought to be between one in 100 and one in 1,000, the polio virus attacks the nerves in the spine and base of the brain. This can cause paralysis, usually in the legs. If the breathing muscles are affected, it can be life-threatening.

 

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UK Government Signs Contract for COVID-19 Challenge Trial 

UK Government Signs Contract for COVID-19 Challenge Trial  | Virus World | Scoop.it

The UK government has signed a contract to develop a controversial COVID-19 human challenge trial, where participants will be deliberately infected in a controlled environment with coronavirus to test whether a vaccine is effective. Contract research organisation (CRO) hVIVO, a subsidiary of Open Orphan, has signed the contract with the UK government to develop the trial model. This will involve manufacture of the challenge virus and the first-in-human characterisation study for the virus. The characterisation study, which is expected to be completed in May 2021, still needs ethical and regulatory approval.  It is designed to assess the minimum dose of the virus required, before moving on to the next stage when a vaccine will be administered.

 

The study will be sponsored by Imperial College London and conducted by hVIVO at The Royal Free Hospital’s specialist research unit in London, under the scrutiny of highly trained scientists and medics. hVIVO will also be expanding its clinical operations in London to conduct the trial. It’s not clear which vaccine will be involved in the study – there are several in the last stages of clinical development and the UK government has orders for candidates from AstraZeneca, Pfizer/BioNTech, Novavax, Valneva, Sanofi/GSK and Johnson & Johnson. No financial details of the contract with hVIVO were disclosed.

 

Challenge trials are controversial because of the risks involved with infecting patients with a potentially lethal virus, although with the SARS-CoV-2 coronavirus these could be managed as most people develop mild symptoms and those at high risk of a serious infection are relatively easy to identify. hVIVO is already known for its challenge studies in other infectious diseases, which are conducted a 24-bedroom quarantine clinic with onsite virology, providing individually isolated rooms and connected to a specialist laboratory facility. Open Orphan, which comprises of two commercial CRO services business hVIVO and Venn Life Sciences, has been working on several coronavirus challenge study models and expects to be busy over the next few months helping several pharma and biotech companies test their vaccines. Anyone interested in being contacted and provided with details about future COVID-19 human challenge study research may leave their contact details at www.UKCovidChallenge.com.

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The U.K. Has Identified a New Covid-19 Strain that Spreads More Quickly. Here's What They Know

The U.K. Has Identified a New Covid-19 Strain that Spreads More Quickly. Here's What They Know | Virus World | Scoop.it

So far, there's no evidence to suggest the new strain causes more severe disease or affects Covid treatments and vaccines, England's top medical officer said. U.K. health officials raised the alarm about a variant of the coronavirus that’s spreading quickly across London and southeast England. The variant of Covid-19 has almost two dozen mutations that may affect proteins made by the coronavirus, Patrick Vallance, the U.K.’s chief scientific adviser, said Saturday. It’s rapidly becoming the dominant strain in the capital and the southeast, he said. Scientists have found mutations in areas of the genome “that are known to be associated with how the virus binds to cells and enters cells,” Vallance said in a press briefing alongside Prime Minister Boris Johnson. The changes “cause concern in terms of how the virus looks.” Johnson said there’s no evidence that the variant is more lethal or causes more severe illness than the earlier strains, nor are there indications it will be less susceptible to Covid-19 vaccines that are being rolled out, though the data is still under review. 

Yet it does appear to be as much as 70% more transmissible, and could increase the R value, the number of people infected by a person with the virus, by 0.4, Johnson said.

 

Curbing Transmission

Viruses are typically genetically unstable, and their constant mutations give them opportunities to infect new organisms, as the coronavirus did last year when it likely jumped from animals to humans. Scientists expressed concern that the increasing spread of the pathogen, which has already infected more than 75 million people worldwide, may give it the chance to change into a more lethal form. “We have to reduce transmission to prevent hospitalisations & deaths,” Jeremy Farrar, an infectious disease specialist and director of Wellcome, the U.K. research foundation, said on Twitter. “We also have to reduce transmission to reduce opportunity for virus to evolve & escape control.” Changes in viruses have the potential to lead in different directions, curbing transmission and virulence but also possibly moving in a more severe direction, he wrote. It’s too early to know if it’s becoming more dangerous, he added. While many aspects of the pandemic have been predictable since the start of the year, “we may be entering a less predictable phase.” Johnson initiated a new round of restrictions on Saturday as the U.K. reported 27,052 new cases, bringing the total to more than 2 million. The country reached 1 million cases on Oct. 31. The prime minister imposed a lockdown on London and large parts of southeast England. He canceled plans to ease pandemic restrictions for five days over the holidays, and banned household mixing in London and the southeast while restricting socializing to just Christmas Day across the rest of England....

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