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Virus World provides a daily blog of the latest news in the Virology field and the COVID-19 pandemic. News on new antiviral drugs, vaccines, diagnostic tests, viral outbreaks, novel viruses and milestone discoveries are curated by expert virologists. Highlighted news include trending and most cited scientific articles in these fields with links to the original publications. Stay up-to-date with the most exciting discoveries in the virus world and the last therapies for COVID-19 without spending hours browsing news and scientific publications. Additional comments by experts on the topics are available in Linkedin (https://www.linkedin.com/in/juanlama/detail/recent-activity/)
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New drugs and more effective treatment regimens for HIV featured at IAS 2019

New drugs and more effective treatment regimens for HIV featured at IAS 2019 | Virus World | Scoop.it
From mailchi.mp - July 24, 2019 5:45 PM

 New evidence released today at the 10th IAS Conference on HIV Science (IAS 2019) highlights important advancements in antiretroviral therapy, including new and more efficient regimens with the potential to change the treatment landscape.
 
“New drugs and novel treatment regimens have the potential to improve long-term tolerability and reduce costs and pill sizes,” IAS President and IAS 2019 International Scientific Chair Anton Pozniak said.

 

Moving from three- to two-drug regimens 
Two studies presented the safety and efficacy of dolutegravir (DTG) plus lamivudine (3TC) in two-drug therapy: for people starting treatment for the first time; and for people who switch after being virally suppressed on another regimen. The new analysis includes 96 weeks of data. It finds that the two-drug regimen remains non-inferior to the three-drug regimen over this two-year period.

 

A new HIV treatment drug
 IAS 2019 also featured promising data on MK-8591, the first drug in a new class of treatments known as nucleoside transcriptase translocation inhibitors (NRTTIs). The authors presented 48-week data from a Phase 2B, randomized trial in which MK-8591 was used as part of first-line therapy. After 48 weeks of treatment, rates of viral suppression were similar in all study arms, ranging from 78% to 90% in patients receiving MK-8591, and 84% in those on the three-drug combination without MK-8591.

 

Every other day antiretroviral maintenance strategy
 Another analysis focused on reducing the number of pills that a person living with HIV must take. Specifically, this open-label, randomized Phase III study compared the use of typical three-drug regimens taken four days per week with daily use.  After 48 weeks of treatment, the four-days-per-week approach was found to be non-inferior to everyday treatment, in terms of maintaining viral suppression. These findings offer further evidence that newer HIV treatment drugs can be used in innovative ways.

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good health's curator insight, January 10, 10:36 AM

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Gilead Presents Proof-of-Concept Data for GS-6207, a First-in-Class Capsid Inhibitor, in People Living With HIV

Gilead Presents Proof-of-Concept Data for GS-6207, a First-in-Class Capsid Inhibitor, in People Living With HIV | Virus World | Scoop.it
From www.gilead.com - July 22, 2019 1:15 PM

Gilead Presents Proof-of-Concept Data for GS-6207, a First-in-Class Capsid Inhibitor, in People Living With HIV.

 

Gilead Sciences, Inc. (NASDAQ: GILD) today presented the first clinical data in people living with HIV on GS-6207, an investigational, novel, selective, first-in-class inhibitor of HIV capsid function. The Phase 1b data demonstrate the first proof of concept that HIV capsid inhibition can lead to significant declines in viral load in vivo. In addition, Gilead presented preclinical data demonstrating that resistance to GS-6207 in vitro did not lead to resistance to other classes of drugs used in the treatment of HIV. These data were presented at the 10thInternational AIDS Society Conference on HIV Science (IAS 2019) in Mexico City.

 

GS-6207 is an investigational long-acting antiretroviral agent that can be delivered subcutaneously. GS-6207 recently received breakthrough therapy designation from the U.S. Food and Drug Administration (FDA) as a potential therapy for heavily treatment-experienced people living with multi-drug resistant HIV. GS-6207 acts in a novel way compared with currently available antiretroviral agents by interrupting the activity of HIV capsid, a protein that surrounds and protects the virus’ genetic material and essential enzymes. GS-6207 may interrupt multiple distinct stages of the viral lifecycle, potentially preventing the virus from becoming infectious and gaining access to uninfected cells.

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