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Virus World provides a daily blog of the latest news in the Virology field and the COVID-19 pandemic. News on new antiviral drugs, vaccines, diagnostic tests, viral outbreaks, novel viruses and milestone discoveries are curated by expert virologists. Highlighted news include trending and most cited scientific articles in these fields with links to the original publications. Stay up-to-date with the most exciting discoveries in the virus world and the last therapies for COVID-19 without spending hours browsing news and scientific publications. Additional comments by experts on the topics are available in Linkedin (https://www.linkedin.com/in/juanlama/detail/recent-activity/)
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Rare Monkeypox Virus Reported in Dallas Resident

Rare Monkeypox Virus Reported in Dallas Resident | Virus World | Scoop.it

Dallas County health authorities are reporting a case of rare monkeypox virus in an individual who traveled from Nigeria to Dallas. The person, a Dallas city resident, is hospitalized and in stable condition, according to a statement Friday from the Dallas County Department of Health and Human Services. The Centers for Disease Control and Prevention is working with Delta Air Lines and state and local health officials to contact airline passengers and others who may have been in contact with the patient during two flights: from Lagos, Nigeria, to Atlanta on July 8, with arrival July 9; and Atlanta to Dallas Love Field Airport on July 9. Public health authorities said they have identified and are in contact with individuals who were in direct contact with the patient.  Travelers were required to wear masks on the flights as well as in the U.S. airports because of the ongoing coronavirus pandemic. “Therefore, it’s believed the risk of spread of monkeypox via respiratory droplets to others on the planes and in the airports is low,” the Dallas County statement said. Monkeypox is a rare but potentially serious viral illness that typically begins with flu-like symptoms and swelling of the lymph nodes, progressing to a widespread rash on the face and body. Most infections last two to four weeks. Monkeypox is in the same family of viruses as smallpox but causes a milder infection.

 

In this case, CDC laboratory testing showed the patient is infected with a strain of monkeypox most commonly seen in parts of West Africa, including Nigeria. Infections with this strain are fatal in about 1 in 100 people, according to a CDC statement. However, rates can be higher in people with weakened immune systems. There is no proven safe treatment for monkeypox virus infection. The patient developed a rash just before departing Nigeria, but the rash worsened after the person returned home to Dallas, according to an official familiar with the investigation who was not authorized to speak publicly on the matter because of the ongoing probe. The person went to the hospital Tuesday. Clinicians quickly made the diagnosis based on the symptoms and recent travel history from Nigeria. By then, the person had developed the characteristic symptoms: rashes on their face and elsewhere on the body. Authorities said they have interviewed the patient and close contacts who were exposed and determined there is very little risk to general public. People who do not have symptoms are not capable of spreading the virus to others. Dallas County said it is not releasing additional information about the patient or the patient’s location. The individual is isolated at the hospital to prevent the spread of the virus.

 

“While rare, this case is not a reason for alarm and we do not expect any threat to the general public,” Dallas County Judge Clay Jenkins said. Philip Huang, director of Dallas County Health and Human Services, said the case demonstrates “the importance of maintaining a strong public health infrastructure, as we are only a plane ride away from any global infectious disease.” Before the Dallas case, there have been at least six reported monkeypox cases in travelers returning from Nigeria, including cases in the United Kingdom, Israel and Singapore. This instance is not related to any of the previous cases. In the United Kingdom, several additional monkeypox cases occurred in those who had contact with infected people. Most monkeypox outbreaks have occurred in Africa. In addition to Nigeria, outbreaks have also been reported in nine other countries in central and western Africa since 1970. Monkeypox also caused a large outbreak in people in the United States in 2003 after the virus spread from imported African rodents to pet prairie dogs, with 47 reported human cases.

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The World Health Organization Declares Africa Polio-Free

The World Health Organization Declares Africa Polio-Free | Virus World | Scoop.it

After a 32-year campaign to rid the African continent of wild poliovirus, the World Health Organization declared Africa entirely polio-free. Nobody will ever know the identity of the thousands of African children who were not killed or paralyzed by polio this year. They would have been hard to keep track of no matter what because in ordinary times, they would have followed thousands last year and thousands the year before and on back in a generations-long trail of suffering and death. Instead, no African children were claimed by polio this year or last year or the year before. It was in 2016 that the last case of wild, circulating polio was reported in Nigeria—the final country on the 54-nation African continent where the disease was endemic. And with a required multi-year waiting period now having passed with no more cases, the World Health Organization today officially declared the entirety of Africa polio-free. A disease that as recently as the late 1980s was endemic in 125 countries, claiming 350,000 children per year, has now been run to ground in just two remaining places, Pakistan and Afghanistan, where there have been a collective 102 cases so far in 2020. That’s 102 too many, but there is no denying the scope of the WHO announcement. “Today’s victory over the wild poliovirus in the African region is a testament to what can happen when partners from a variety of sectors join forces to accomplish a major global health goal,” says John Hewko, general secretary and CEO of Rotary International. “[It is] something the world can and should aspire to during these turbulent times.”

 

It was Rotary, an international nonprofit service organization, that kicked off the polio endgame in 1988 with the launch of the Global Polio Eradication Initiative (GPEI). That program aimed to leverage the power of Rotary’s 35,000 clubs and 1.22 million members in 200 countries and territories worldwide to make polio only the second human disease—after smallpox—to be pushed over the brink of extinction. The job was made easier by the partners Rotary immediately attracted: the WHO, the U.S. Centers for Disease Control and Prevention (CDC) and UNICEF. The Bill and Melinda Gates Foundation joined in 2007, followed by Gavi, the Vaccine Alliance, just last year. The 32-year initiative has depended on volunteer workers and charitable donations, which together have produced an army of 20 million field workers administering vaccines to over 2.5 billion children at a cost of $17 billion. Some countries were a lighter lift than others. In the U.S. the disease was eradicated in 1979, well before the GPEI even began its work. Other nations followed: In 1994 the Americas were declared polio-free. Europe as a whole got a clean bill of health in 2002, when all 53 countries in the WHO’s designated European region were declared free of the virus. Massive vaccination efforts began in India in 1997, which eradicated the virus in 2014. 

How Polio Was Eradicated from the African Continent

But Africa, with its vast sprawl of village populations, long distances to urban hospitals, spotty infrastructure like adequate roads and reliable “cold chains”—refrigerated transport networks to keep vaccines viable—was always going to present special challenges. In 1996, when the case count on the continent regularly reached 75,000 victims every year, South African President Nelson Mandela partnered with Rotary to launch the “Kick Polio Out of Africa” Campaign, and the group scrambled fast—or as fast as was possible with so many children to vaccinate on so vast a land mass. In 2000, the first synchronized campaigns began in 17 countries, with 76 million children being vaccinated by tens of thousands of volunteers. The work fanned out across the continent from there, including an especially heavy push from 2008 to 2010, when an outbreak in 24 countries in western and central Africa was met by a large-scale, multi-national vaccination of 85 million children. Finally, Nigeria stood alone as the only African nation where the disease was still endemic, in part because of resistance by religious leaders in the northern part of the country who objected western interference in local affairs and claimed that the vaccine was unsafe. That opposition broke down, partly thanks to Muhammad Sanusi II, the Emir of the city of Kano—a hereditary leader descended from a ruling family—who appeared at a public ceremony before the kick off of a seasonal vaccination campaign in 2016, called for a vial of polio vaccine to be brought to the stage, and with the audience watching, broke its seal and drank down its entire contents. That year, the country recorded its last case of polio, and this year, Nigeria’s WHO certification is the reward for its efforts....

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