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Virus World provides a daily blog of the latest news in the Virology field and the COVID-19 pandemic. News on new antiviral drugs, vaccines, diagnostic tests, viral outbreaks, novel viruses and milestone discoveries are curated by expert virologists. Highlighted news include trending and most cited scientific articles in these fields with links to the original publications. Stay up-to-date with the most exciting discoveries in the virus world and the last therapies for COVID-19 without spending hours browsing news and scientific publications. Additional comments by experts on the topics are available in Linkedin (https://www.linkedin.com/in/juanlama/detail/recent-activity/)
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FDA Approves First Long-Acting Injectable for HIV Prevention

FDA Approves First Long-Acting Injectable for HIV Prevention | Virus World | Scoop.it

The FDA on Monday approved ViiV Healthcare’s cabotegravir as the first long-acting injectable for HIV PrEP. The medication, which will be known as Apretude, is administered every 2 months after two initial injections that are given 1 month apart. The FDA approved it for at-risk adults and adolescents weighing at least 77 pounds.  Debra Birnkrant, MD, who heads the Division of Antivirals in the FDA’s Center for Drug Evaluation and Research, said the approval “adds an important tool in the effort to end the HIV epidemic by providing the first option to prevent HIV that does not involve taking a daily pill.” “This injection ... will be critical to addressing the HIV epidemic in the U.S., including helping high-risk individuals and certain groups where adherence to daily medication has been a major challenge or not a realistic option,” Birnkrant said in a news release. Anticipating the approval, the CDC included a section on prescribing cabotegravir in its updated clinical practice guideline for HIV PrEP published 2 weeks ago. The CDC also recommended for the first time that clinicians tell all sexually active adult and adolescent patients about HIV PrEP in light of evidence that only around 25% of the 1.2 million people in the United States who met the indication for PrEP in 2020 were prescribed it.

 

The FDA approval was based on study findings that showed cabotegravir administered every 8 weeks prevented HIV infection. Two trials provided the data: one that was conducted among transgender women and cisgender men who have sex with men, and a second trial that included only cisgender women. “People who are vulnerable to acquiring HIV, especially those in Black and Latinx communities who are disproportionately impacted in the U.S., may want options beyond daily oral pills. That’s why ViiV Healthcare is proud that Apretude was studied in one of the most diverse and comprehensive HIV prevention trial programs to date, which also included some of the largest numbers of transgender women and Black men who have sex with men ever enrolled in an HIV prevention trial,” ViiV CEO Deborah Waterhouse said in a statement. Cabotegravir was already part of the first FDA-approved long-acting injectable regimen for HIV treatment, Cabenuva, which also includes rilpivirine.

 

FDA Press Release (Dec. 20, 2021):

https://www.fda.gov/news-events/press-announcements/fda-approves-first-injectable-treatment-hiv-pre-exposure-prevention 

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Gilead's Descovy Approved for HIV Prevention

Gilead's Descovy Approved for HIV Prevention | Virus World | Scoop.it

The U.S. Food and Drug Administration (FDA) approved  Gilead Science's Descovy for HIV pre-exposure prophylaxis (PrEP). Descovy is a doublet combination of 200 mg of emtricitabine and 25 mg of tenofovir alafenamide. It was not approved, however, for at-risk individuals from receptive vaginal sex because it hasn’t been tested for that indication.

 

Descovy was approved for this indication under the FDA’s priority review designation. The drug also carries a Boxed Warning in the U.S. because of the risk of post treatment acute exacerbation of hepatitis B. It also includes a Boxed Warning over the risk of drug resistance with PrEP use in undiagnosed early HIV-1 infection.

 

The supplemental New Drug Application (sNDA) was built on the DISCOVER Phase III clinical trial results. This trial evaluated more than 5,300 adult cisgender men who have sex with men or transgender women who have sex with men. The primary efficacy endpoint was the incidence of documented HIV infection per 100 person-years after follow-up for at least 48 weeks and at least half of the group had a follow-up at 96 weeks. “Descovy for PrEP provides a new HIV prevention option that matches Truvada’s high efficacy with statistically significant improvements in renal and bone safety, which can be an important consideration as people at risk increasingly use PrEP for longer periods of time,” said Daniel O’Day, chairman and chief executive officer of Gilead. “This is a reflection of Gilead’s continued commitment to addressing the evolving needs of people living with or at risk for HIV and to driving innovation across the HIV care continuum.”

 

The only other drug currently approved in the U.S. for HIV PrEP is Gilead’s Truvada (emtricitabine 200 mg/tenofovir disoproxil fumarate 300 mg). In the DISCOVER trial, Descovy was found to be noninferior to Truvada in terms of efficacy for this patient population, and there were significant advantages over Truvada for six pre-specified secondary endpoints related to renal and bone laboratory parameters. “PrEP drugs are highly effective when taken as indicated in the drug labeling and can prevent HIV infection,” stated Jeffrey Murray, deputy director of the Division of Antiviral Products in the FDA’s Center for Drug Evaluation and Research. “This approval provides more prevention options for certain patients at-risk for acquiring HIV and helps further efforts by the FDA and the U.S. Department of Health and Human Services to facilitate the development of HIV treatment and prevention options to reduce new HIV infections.”

 

HIV PrEP has come with some controversy. Truvada runs about $20,000 a year. A generic version is expected to hit the market in 2020. The Trump Administration has indicated it wants to increase access to PrEP as part of its efforts to end HIV transmission by 2030. However, in a U.S. House of Representatives hearing in May, O’Day took some heat for the price of the drug that had some government research funding.

 

Summary of Results of DISCOVER Trial:

https://www.gilead.com/news-and-press/press-room/press-releases/2019/3/gilead-announces-data-demonstrating-noninferiority-of-oncedaily-descovy-vs-oncedaily-truvada-for-prevention-of-hiv-infection

good health's curator insight, January 10, 9:09 AM

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