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Virus World provides a daily blog of the latest news in the Virology field and the COVID-19 pandemic. News on new antiviral drugs, vaccines, diagnostic tests, viral outbreaks, novel viruses and milestone discoveries are curated by expert virologists. Highlighted news include trending and most cited scientific articles in these fields with links to the original publications. Stay up-to-date with the most exciting discoveries in the virus world and the last therapies for COVID-19 without spending hours browsing news and scientific publications. Additional comments by experts on the topics are available in Linkedin (https://www.linkedin.com/in/juanlama/detail/recent-activity/)
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How the Rich and Privileged Can Skip the Line for Covid-19 Vaccines

How the Rich and Privileged Can Skip the Line for Covid-19 Vaccines | Virus World | Scoop.it

“Anything that’s seen as lifesaving, life-preserving, and that's in short supply creates black markets,” said one ethicist. Bill Lang didn’t get much of a break over Thanksgiving. Almost every day last week, the medical director at a high-end concierge medical practice, WorldClinic, heard from clients asking when a Covid-19 vaccine would be available. Two patients even texted on Thanksgiving day. “Since then, I’ve had at least three texts or calls every day just asking, ‘When do you think I can get a vaccine?’” said Lang, who is based in Washington, but also speaks with patients across the U.S. and internationally. Athletes, politicians, and other wealthy or well-connected people have managed to get special treatment throughout the pandemic, including preferential access to testing and unapproved therapies. Early access to coronavirus vaccines is likely to be no different, medical experts and ethicists told STAT. It could happen in any number of ways, they said: fudging the definition of “essential workers” or “high-risk” conditions, lobbying by influential industries, physicians caving to pressure to keep their patients happy, and even through outright bribery or theft. The worst attempts to nefariously procure a vaccine may come a few months into distribution, once vaccines are available that don’t require ultra-cold storage and local pharmacies and physician practices get allotments. “There absolutely will be a black market,” said bioethicist Arthur Caplan of New York University. “Anything that’s seen as lifesaving, life-preserving, and that’s in short supply creates black markets.”

 

At WorldClinic, which charges members $10,000 to $250,000 a year for 24/7 care, no patients have asked for special treatment and the clinic would not undermine its integrity by trying to secure vaccines unethically, said Lang, who was a White House physician during both the Bush and Clinton administrations. “The optics of trying to jump the line would be so bad, they don’t want to do that.” But within the broader system, he added, some people will inevitably cut in line. “Essential workers” are expected to receive early access to the vaccine, and the definition of this category is open to interpretation by state health departments, creating a means for influential industries to lobby for priority. “The devil’s going to be in the details of how the state runs their program,” Lang said he tells his patients. Members of the Advisory Committee on Immunization Practices (ACIP), the federal panel recommending how to distribute the vaccines, want to prioritize essential workers to help ensure people of color, who are often the hardest hit by the virus, get early access. But the predominantly white workers in the financial services industry are also considered essential, according to guidance from the Cybersecurity and Infrastructure Security Agency, which was referenced by ACIP, as well as executive orders from several states including New YorkIllinoisColorado, and California. Public-facing bank tellers face contagion risks in their work, but aren’t the only financial services employees included. “It was left a little bit nebulous but basically covered people who oil the movement of money, so exchanges, trading floors, trading operations, and people who keep money moving at the retail [banking] level,” said Lang. “They’re defined very broadly in New York and Illinois, because that’s where so many of our financial services industries are based.”

 

The concept of “essential workers” has already been tested during the pandemic, when Florida declared that World Wrestling Entertainment (WWE) met the definition and could remain open during lockdown. The chairman of WWE, Vince McMahon, is friends with President Trump, while his wife, Linda McMahon, served in the administration and is chair of a pro-Trump super PAC. Neither WWE nor Florida’s health department responded to requests for comment about whether WWE would be considered essential for the vaccine rollout. Other powerful industries might be tempted to follow this example. The potential of industry lobbyists “redefining what an essential worker is is a very strong possibility,” said Glenn Ellis, a visiting scholar at the National Center for Bioethics in Research and Health care at Tuskegee University and a narrative bioethics fellow at Harvard Medical School. Prioritizing essential workers is intended to give early vaccine access to those who provide a critical societal function and cannot socially distance easily, the Colorado health department said in a statement that acknowledged it can be difficult to write airtight rules. “Given the thousands of different job descriptions in the state, it is impossible to come up with a complete list for every occupation for a specific vaccine phase. Vaccine providers will need to use their best judgment about which patients may qualify for vaccination during this phase.”  The California health department confirmed financial services employees, including those needed to “maintain orderly market operations,” will have early access to the vaccine as essential workers, as will people in the news media, such as reporters. State health departments in New York and Illinois did not respond to requests for comment about whether those in financial services would receive a vaccine early.

 

Another opening that could be exploited to skip the line involves high-risk medical conditions that warrant early access to the vaccine. Smokers are within this group, according to ACIP, and people with conditions such as moderate-to-severe asthma and high blood pressure could also be included.  This leaves room for a doctor to, for example, portray a patient’s mild asthma as severe enough to justify early access to a vaccine, said Jonathan Cushing, head of major projects of the health initiative at Transparency International, a nonprofit focused on global corruption. The profit motives within U.S. health care make it particularly susceptible to such distortions, he said: “It’s a market-based economy. You as a doctor want to keep your clients coming back.” Given the need to protect patient privacy, Lang said he doesn’t expect immunization sites to demand documentation of health risk factors. Instead, they will likely either ask patients to state that they have one of the relevant conditions, without disclosing details, or require physician certification, he said: “A lot of that is left to a doctor’s judgment.”  Exaggerating sickness is not a new phenomenon in the U.S. medical system. Insurance companies have portrayed Medicare patients as sicker than they really are, so as to receive higher government payouts. Similarly, physicians to wealthy patients could “make sure they’re among the first to get the vaccines by fudging it in a way that would enable their clients to cut in line” said Wendell Potter, former head of corporate communications at Cigna and current head of the nonprofit Center for Health and Democracy.....

Zach Hall's curator insight, December 7, 2020 5:52 PM
This is disappointing yet predictable, the rich have always been catered to
Lydia McGarvey's curator insight, December 8, 2020 10:46 AM
This is completely wrong!  No one is more important than others.  Your economic/financial situation should not be a reason for you to skip the lines and receive the vaccine first.  Something needs to be done about this through our government.
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Factors Associated with COVID-19 Death in 17 million Patients

Factors Associated with COVID-19 Death in 17 million Patients | Virus World | Scoop.it

COVID-19 has rapidly affected mortality worldwide1. There is unprecedented urgency to understand who is most at risk of severe outcomes, requiring new approaches for timely analysis of large datasets. Working on behalf of NHS England, here we created OpenSAFELY: a secure health analytics platform covering 40% of all patients in England, holding patient data within the existing data centre of a major primary care electronic health records vendor.

 

Primary care records of 17,278,392 adults were pseudonymously linked to 10,926 COVID-19-related deaths. COVID-19-related death was associated with: being male (hazard ratio (HR) 1.59, 95% confidence interval (CI) 1.53–1.65); older age and deprivation (both with a strong gradient); diabetes; severe asthma; and various other medical conditions. Compared with people with white ethnicity, Black and South Asian people were at higher risk even after adjustment for other factors (HR 1.48, 1.30–1.69 and 1.44, 1.32–1.58, respectively).

 

We have quantified a range of clinical risk factors for COVID-19-related death in the largest cohort study conducted by any country to date. OpenSAFELY is rapidly adding further patients’ records; we will update and extend results regularly.

 

Original Study available at Nature (July 8, 2020):

https://doi.org/10.1038/s41586-020-2521-4

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Kidney Function Indicators Predict Adverse Outcomes of COVID-19

Kidney Function Indicators Predict Adverse Outcomes of COVID-19 | Virus World | Scoop.it
The coronavirus disease 2019 (COVID-19) is an emerged respiratory infectious disease with kidney injury as a part of the clinical complications. However, the dynamic change of kidney function and its association with COVID-19 prognosis are largely unknown. In this multicenter retrospective cohort study, we analyzed clinical characteristics, medical history, laboratory tests, and treatment data of 12,413 COVID-19 patients. The patient cohort was stratified according to the severity of the outcome into three groups: non-severe, severe, and death.
 
The prevalence of elevated blood urea nitrogen (BUN), elevated serum creatinine (Scr), and decreased blood uric acid (BUA) at admission was 6.29%, 5.22%, 11.66%, respectively. The trajectories showed elevation of BUN level and Scr level, as well as a reduction of BUA level during 28 days after admission in death cases. Increased all-cause mortality risk was associated with elevated baseline levels of BUN and Scr, and decreased level of BUA The dynamic changes of the three kidney function markers were associated with different severity and poor prognosis of COVID-19 patients. BUN showed close association and high potential for predicting adverse outcomes in COVID-19 patients for severity stratification and triage.
 
Published in Med (October 2, 2020)
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