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Virus World provides a daily blog of the latest news in the Virology field and the COVID-19 pandemic. News on new antiviral drugs, vaccines, diagnostic tests, viral outbreaks, novel viruses and milestone discoveries are curated by expert virologists. Highlighted news include trending and most cited scientific articles in these fields with links to the original publications. Stay up-to-date with the most exciting discoveries in the virus world and the last therapies for COVID-19 without spending hours browsing news and scientific publications. Additional comments by experts on the topics are available in Linkedin (https://www.linkedin.com/in/juanlama/detail/recent-activity/)
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First Confirmed US Case of Omicron Coronavirus Variant Detected in California

First Confirmed US Case of Omicron Coronavirus Variant Detected in California | Virus World | Scoop.it

(CNN)The United States' first confirmed case of the Omicron coronavirus variant has been identified in California. In a White House news briefing, Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said the case was in an individual who traveled from South Africa on November 22 and tested positive for Covid-19 on November 29.  That individual, Fauci said, is self-quarantining and close contacts have tested negative for the coronavirus so far. The person was fully vaccinated and is experiencing "mild symptoms, which are improving at this point," Fauci said.  Asked by CNN whether that person had a booster shot, Fauci said, "To my knowledge, no."

The California and San Francisco public health departments confirmed the case was caused by the Omicron variant through genomic sequencing conducted at the University of California at San Francisco, and the sequence was confirmed by the US Centers for Disease Control and Prevention.
 
Color Health said in a statement it returned the positive test result through a San Francisco Covid-19 testing program, and Omicron was identified in under 30 hours "from the time of collection to strain confirmation."  The World Health Organization designates Omicron a "variant of concern." In a technical brief released this week, WHO noted that the variant poses a "very high" global risk. The variant was first identified by scientists in South Africa, and has since been detected in several countries. Scientists are working to determine how transmissible the variant is, how sick it makes people and how well current vaccines work against it. Until more information is learned about the variant, the United States restricted travel from South Africa and seven other countries.  On Monday, President Joe Biden called the variant "a cause for concern, not a cause for panic," saying "we'll have to face this new threat just as we face those who have come before it." Health officials are urging people to get vaccinated against Covid-19, or get a booster if they're eligible. Other measures such as masks, handwashing, physical distancing and ventilation will still work against the Omicron variant. The Delta variant of the coronavirus remains the dominant variant globally and in the United States.
 
Smith Rowe's curator insight, December 2, 2021 12:50 PM
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Predominance of Antibody-Resistant SARS-CoV-2 Variants in Vaccine Breakthrough Cases From The San Francisco Bay Area

Predominance of Antibody-Resistant SARS-CoV-2 Variants in Vaccine Breakthrough Cases From The San Francisco Bay Area | Virus World | Scoop.it

Associations between vaccine breakthrough cases and infection by SARS coronavirus 2 (SARS-CoV-2) variants have remained largely unexplored. Here we analyzed SARS-CoV-2 whole-genome sequences and viral loads from 1,373 persons with COVID-19 from the San Francisco Bay Area from February 1 to June 30, 2021, of which 125 (9.1%) were vaccine breakthrough infections. Fully vaccinated were more likely than unvaccinated persons to be infected by variants carrying mutations associated with decreased antibody neutralization (L452R, L452Q, E484K, and/or F490S) (78% versus 48%, p = 1.96e-08), but not by those associated with increased infectivity (L452R and/or N501Y) (85% versus 77%, p = 0.092). Differences in viral loads were non-significant between unvaccinated and fully vaccinated persons overall (p = 0.99) and according to lineage (p = 0.09 – 0.78). Viral loads were significantly higher in symptomatic as compared to asymptomatic vaccine breakthrough cases (p < 0.0001), and symptomatic vaccine breakthrough infections had similar viral loads to unvaccinated infections (p = 0.64).

 

In 5 cases with available longitudinal samples for serologic analyses, vaccine breakthrough infections were found to be associated with low or undetectable neutralizing antibody levels attributable to immunocompromised state or infection by an antibody-resistant lineage. These findings suggest that vaccine breakthrough cases are preferentially caused by circulating antibody-resistant SARS-CoV-2 variants, and that symptomatic breakthrough infections may potentially transmit COVID-19 as efficiently as unvaccinated infections, regardless of the infecting lineage.

 

Preprint available in medRxiv (August 25, 2021):

https://doi.org/10.1101/2021.08.19.21262139 

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