Coronavirus Disease 2019 (COVID-19) vaccines protect the public and limit viral spread. However, inactivated viral vaccines use the whole virus particle, which contains many non-capsid proteins that may cause adverse immune responses. A report has found that the ADP-ribose-binding domains of SARS-CoV-2 non-structural protein 3 (NSP3) and human poly(ADP-ribose) polymerase family member 14 (PARP14) share a significant degree of homology. Here, we further show that antibodies against 2019 novel SARS-like coronavirus (SARS-CoV-2) NSP3 can bind human PARP14 protein. However, when G159R + G162R mutations were introduced into NSP3, the antibody titer against human PARP14 decreased 14-fold.
Antibodies against SARS-CoV-2 NSP3 can cross-react with human skeletal muscle cells and astrocytes, but not human embryonic kidney 293T cells. However, when G159R + G162R mutations were introduced into NSP3, the cross-reaction was largely inhibited. The results imply that COVID-19 patients with high antibody titers against NSP3 may have high risks of muscular and/or neurological complications. And the possible strategies to improve the safety of inactivated viral vaccines are also discussed.
Published in Vaccine (Jan. 27, 2024): https://doi.org/10.1016/j.vaccine.2024.01.074
Amazing
https://buypsychedelicdrugs.com/product-category/dmt/
https://buypsychedelicdrugs.com/product/5-meo-dmt/
https://buypsychedelicdrugs.com/product/4-aco-dmt/
https://buypsychedelicdrugs.com/product/ayahuasca/
https://buypsychedelicdrugs.com/product/changa-dmt/
https://buypsychedelicdrugs.com/product/buy-dmt-vape-pen/
https://buypsychedelicdrugs.com/product/lsd-tabs/
https://buypsychedelicdrugs.com/product/buy-mimosa-hostilis-root-bark-powdered-mhrb/
https://buypsychedelicdrugs.com/product/nn-dmt/
https://buypsychedelicdrugs.com/product/amanita-muscaria/
https://buypsychedelicdrugs.com/product/buy-dragons-dynamite-truffles/
https://buypsychedelicdrugs.com/product/golden-teachers/
https://buypsychedelicdrugs.com/product/buy-high-hawaiians-truffles/
https://buypsychedelicdrugs.com/product/liberty-caps/
https://buypsychedelicdrugs.com/product/buy-microdosing-psilocybin-truffles-10-pack/
https://buypsychedelicdrugs.com/product/buy-microdosing-psilocybin-truffles-2-pack-in-stock/
https://buypsychedelicdrugs.com/product/buy-microdosing-psilocybin-truffles-20-pack/
https://buypsychedelicdrugs.com/product/golden-teachers/
https://buypsychedelicdrugs.com/product/buy-penis-envy-mushroom/
https://buypsychedelicdrugs.com/product/codeine-promethazine/
https://buypsychedelicdrugs.com/product/ecstasy-mdma/
https://buypsychedelicdrugs.com/product/microdosing-psilocybin-truffles-1-pack-for-sale/
https://buypsychedelicdrugs.com/product/mush-rocks-truffles-for-sale/
https://buypsychedelicdrugs.com/product/pcp-powder/
https://buypsychedelicdrugs.com/product/cocaine/
https://buypsychedelicdrugs.com/product/methamphetamine/
https://buypsychedelicdrugs.com/product/xanax/
https://buypsychedelicdrugs.com/product/lsd-gel-tabs/
https://buypsychedelicdrugs.com/product/lsd-liquid/
https://caluaniemuelearoxidizeusa.com/product/buy-10l-caluanie-muelear-pasteurize/
https://caluaniemuelearoxidizeusa.com/product/buy-20l-caluanie-muelear-oxidize/
https://caluaniemuelearoxidizeusa.com/product/buy-5l-caluanie-muelear-pasteurize/
https://caluaniemuelearoxidizeusa.com/product/buy-caluanie-muelear-pasteurize/
Amazing
https://buypsychedelicdrugs.com/product-category/dmt/
https://buypsychedelicdrugs.com/product/5-meo-dmt/
https://buypsychedelicdrugs.com/product/4-aco-dmt/
https://buypsychedelicdrugs.com/product/ayahuasca/
https://buypsychedelicdrugs.com/product/changa-dmt/
https://buypsychedelicdrugs.com/product/buy-dmt-vape-pen/
https://buypsychedelicdrugs.com/product/lsd-tabs/
https://buypsychedelicdrugs.com/product/buy-mimosa-hostilis-root-bark-powdered-mhrb/
https://buypsychedelicdrugs.com/product/nn-dmt/
https://buypsychedelicdrugs.com/product/amanita-muscaria/
https://buypsychedelicdrugs.com/product/buy-dragons-dynamite-truffles/
https://buypsychedelicdrugs.com/product/golden-teachers/
https://buypsychedelicdrugs.com/product/buy-high-hawaiians-truffles/
https://buypsychedelicdrugs.com/product/liberty-caps/
https://buypsychedelicdrugs.com/product/buy-microdosing-psilocybin-truffles-10-pack/
https://buypsychedelicdrugs.com/product/buy-microdosing-psilocybin-truffles-2-pack-in-stock/
https://buypsychedelicdrugs.com/product/buy-microdosing-psilocybin-truffles-20-pack/
https://buypsychedelicdrugs.com/product/golden-teachers/
https://buypsychedelicdrugs.com/product/buy-penis-envy-mushroom/
https://buypsychedelicdrugs.com/product/codeine-promethazine/
https://buypsychedelicdrugs.com/product/ecstasy-mdma/
https://buypsychedelicdrugs.com/product/microdosing-psilocybin-truffles-1-pack-for-sale/
https://buypsychedelicdrugs.com/product/mush-rocks-truffles-for-sale/
https://buypsychedelicdrugs.com/product/pcp-powder/
https://buypsychedelicdrugs.com/product/cocaine/
https://buypsychedelicdrugs.com/product/methamphetamine/
https://buypsychedelicdrugs.com/product/xanax/
https://buypsychedelicdrugs.com/product/lsd-gel-tabs/
https://buypsychedelicdrugs.com/product/lsd-liquid/
https://caluaniemuelearoxidizeusa.com/product/buy-10l-caluanie-muelear-pasteurize/
https://caluaniemuelearoxidizeusa.com/product/buy-20l-caluanie-muelear-oxidize/
https://caluaniemuelearoxidizeusa.com/product/buy-5l-caluanie-muelear-pasteurize/
https://caluaniemuelearoxidizeusa.com/product/buy-caluanie-muelear-pasteurize/