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Whole-genome sequencing and association analysis of 270 Epstein–Barr virus (EBV) isolates from China identify two non-synonymous EBV variants within BALF2 that are strongly associated (odds ratio=8.69) with the risk of nasopharyngeal carcinoma.
These findings provide novel insights into the NPC endemic in southern China and also enable the identification of high-risk individuals for NPC prevention.
https://doi.org/10.1038/s41588-019-0436-5