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Virus World provides a daily blog of the latest news in the Virology field and the COVID-19 pandemic. News on new antiviral drugs, vaccines, diagnostic tests, viral outbreaks, novel viruses and milestone discoveries are curated by expert virologists. Highlighted news include trending and most cited scientific articles in these fields with links to the original publications. Stay up-to-date with the most exciting discoveries in the virus world and the last therapies for COVID-19 without spending hours browsing news and scientific publications. Additional comments by experts on the topics are available in Linkedin (https://www.linkedin.com/in/juanlama/detail/recent-activity/)
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FDA Clears Takeda Drug for Post-Transplant CMV Infections 

FDA Clears Takeda Drug for Post-Transplant CMV Infections  | Virus World | Scoop.it

Takeda has scored the first-ever FDA approval of a treatment for refractory cytomegalovirus (CMV) infections in organ transplant patients, which can lead to an increased risk of complications and even death. Livtencity (maribavir) has been cleared for use in transplant patients aged 12 or over with CMV infections that do not respond to first-line treatment with current antiviral drugs for CMV, such as ganciclovir, valganciclovir, foscarnet and cidofovir. The FDA followed its advisory committee’s advice and backed Livtencity for use regardless of whether patients are infected with CMV strains that have resistance mutations, as checking for these could delay treatment. Maribavir works by blocking the activity of a CMV enzyme called pUL97 that is essential for replication of the virus, and also avoids some of the serious haematological side effects that are associated with the older antivirals. It was one of the drugs acquired by Takeda when it merged with Shire in 2019. The approval marks the culmination of a lengthy development for a drug that failed a phase 3 trial more than a decade ago for CMV prevention in hematopoietic stem cell transplant (HSCT) recipients.

 

Originally developed by GlaxoSmithKline, it was licensed to ViroPharma, which was subsequently bought put by Shire. The approval is based on the phase 3 SOLSTICE trial. which showed Livtencity was superior to conventional antiviral therapies in refractory CMV. More than 55% of transplant recipients with refractory infections achieved confirmed viral clearance with Takeda’s drug, compared to around 24% of those on the older drugs. CMV is one of the most common and serious post-transplant infections with an estimated incidence rate of between 16% and 56% in solid organ transplants, and 30% to 70% in HSCT procedures. Livtencity is one of Takeda’s ‘Wave1’ of new therapies that the company said a couple of years ago could collectively add more than $10 billion in aggregate peak sales, and the drugmaker has previously predicted sales revenues from the drug could top $700 million a year at peak. There’s no word yet on pricing, but Takeda said it would launch the drug “in the coming days.”

Smith Rowe's curator insight, December 2, 2021 1:05 PM
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good health's curator insight, January 10, 9:01 AM

Acquista Online La Prescrizione Di Perdita Di Peso
Crediamo che i farmaci a volte possano essere molto urgenti da assumere. Se hai urgente bisogno di farmaci, possiamo anche fornirti una consegna espressa,


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Scooped by Juan Lama
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Takeda’s CMV med outshines Roche’s Valcyte in phase 2

Takeda’s CMV med outshines Roche’s Valcyte in phase 2 | Virus World | Scoop.it

Takeda’s cytomegalovirus (CMV) drug, maribavir, beat Roche’s Valcyte at clearing the virus from patients’ blood in a phase 2 study. The study compared the drugs in patients with CMV infection after receiving an organ transplant or a stem cell transplant. 

 

Patients who have undergone a transplant are among the most vulnerable to CMV infection because they must take immunosuppressive drugs to ward off organ rejection. CMV doesn’t usually cause symptoms in healthy people, but once someone is infected, the virus stays in their body in a dormant state. However, it can “wake up” in people with weakened immune systems, like transplant patients. 

 

The phase 2, open-label study tested three doses of maribavir in 159 adults, comparing it to Valcyte (valganciclovir). After three weeks of treatment, 62% of patients taking maribavir had no signs of CMV in their blood plasma, compared to 56% of those on Valcyte. After six weeks, 79% of maribavir patients had cleared the virus, compared to 67% of Valcyte patients. The findings appear in the New England Journal of Medicine.  “The Phase 2 study showed that maribavir has demonstrated antiviral activity as a potential treatment of CMV infection and demonstrated a reduction of actively multiplying CMV in the blood, following hematopoietic cell transplant or solid organ transplant,” Takeda said in a statement. 

Takeda is already enrolling two phase 3 studies for maribavir. One will test the drug in stem cell transplant patients with their first CMV infection and the other will test it in patients who have received a stem cell or solid organ transplant and have a resistant or refractory CMBV infection. The second study will pit maribavir against treatments chosen by the study investigators, including Valcyte and a trio of antivirals that were approved in the 1980s and 1990s.  

 

Maribavir’s safety profile may pose a challenge—67% of patients taking maribavir had a treatment-related side effect, compared to 22% of those on Valcyte. Serious side effects, such as acute graft-versus-host disease, diarrhea and renal failure, affected 10% of maribavir patients versus 2% of Valcyte patients. But the lack of treatments for patients with stubborn CMV infections may outweigh these issues. Maribavir has orphan drug status in the U.S. and EU. “There is a significant unmet need for additional treatment for post-transplant patients with CMV infection especially those with a CMV infection that is resistant to currently available antiviral therapies,” said principal investigator Johan Maertens, M.D., Ph.D. of Universitaire Ziekenhuizen Leuven in Leuven, in a statement. “These results are encouraging and warrant further investigation of maribavir as a potentially effective and tolerated treatment for CMV in transplant patients.”  Maribavir, also called TAK-620, has had a checkered past. ViroPharma abandoned a phase 3 CMV trial in 2009 after the drug failed to beat placebo in reducing the rate of CMV in patients who had undergone a bone marrow transplant. Maribavir, along with the hereditary angioedema drug Cinryze in ended up at Shire through its $4.2 billion ViroPharma buyout in 2013, and eventually landed at Takeda following its $62 billion megamerger with Shire.

 

Study published on Sept. 19, 2019 in New England Journal of Medicine:

https://doi.org/10.1056/NEJMoa1714656

 

good health's curator insight, January 10, 9:13 AM

Acquista Online La Prescrizione Di Perdita Di Peso
Crediamo che i farmaci a volte possano essere molto urgenti da assumere. Se hai urgente bisogno di farmaci, possiamo anche fornirti una consegna espressa,


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