Virus World

Microbes living in the rectum could make a difference to the effectiveness of experimental HIV vaccines, according to researchers at the University of California, Davis. The work is published Dec. 11 in the journal mSphere. Evidence from human and animal studies with other vaccines suggests that Lactobacillus supplements can boost production of antibodies, while treatment with antibiotics can hamper beneficial immune responses, said Smita Iyer, assistant professor at the UC Davis Center for Immunology and Infectious Diseases and School of Veterinary Medicine. Iyer, graduate student Sonny Elizaldi and colleagues wanted to know if microbes living in the rectum and vagina — sites of HIV transmission — interacted with an experimental HIV vaccine similar to the HVTN 111 vaccine currently in early stage clinical trials in humans. HVTN 111 includes two doses of HIV DNA snippets and a final boost with an HIV protein, all given through the skin. A vaccine that produces antibodies at the mucosal membranes where infection takes place is thought to be important in preventing HIV infection, Iyer said. The team studied vaginal and rectal microbes from rhesus macaques before and after they were vaccinated. They found that vaginal microbes did not show much difference before and after vaccination. However, rectal microbes did show changes, with Bacteroidetes-type bacteria, especially Prevotella, decreasing after vaccination. 

Lactobacillus bacteria and better immune response

The common gut bacteria Lactobacillus and Clostridia did not change with vaccination, but the amounts of these microbes in the rectum did correlate with the immune response. Animals with high levels of either Lactobacillus or Clostridia made more antibodies to the HIV proteins gp120 and gp140, the researchers found. Prevotella bacteria showed the opposite pattern: High levels of Prevotella were correlated with weaker immune responses. It’s not clear what the mechanism could be for some bacteria to boost local immune responses in a specific site in the body, Iyer said. However, targeting these bacteria could be important to get the best possible performance out of vaccines that do not induce a particularly strong immune response, as is the case with HIV. The microbiome could also be an important but overlooked factor to consider when evaluating vaccines in humans or animals, she said. 

Published in mSphere (December 11, 2019):

https://doi.org/10.1128/mSphere.00824-19

No other emerging pathogen is known to have jumped so frequently from species to species. A virus that killed a six-year-old boy in 1965 has also infected bonobos and chimpanzees in an unprecedented case of viral ‘ping-pong’ between species.

James Chodosh at Harvard Medical School in Boston, Massachusetts, Donald Seto at George Mason University in Manassas, Virginia, and their colleagues reconstructed the history of a long-stored sample of adenovirus, a type of virus that causes colds and other illnesses. By tracking the small changes that accumulated in the virus’s genome when it infected new species, the researchers found that it had previously lived in bonobos (Pan paniscus), chimpanzees (Pan troglodytes) and humans.

The analysis also showed that the pathogen was remarkably similar to an adenovirus recently identified in two groups of primates that had never come into contact with each other: bonobos in the San Diego Zoo in California and chimpanzees in a primate research facility in Louisiana. The results suggest that the transmission of adenoviruses to humans from other animals might have an important role in the emergence of pathogens that could harm human health.

The original findings were published in the Journal of Virology: https://doi.org/10.1128/JVI.00564-19