Virus World

Pfizer and BioNTech said three doses of their Covid-19 vaccine neutralize the Omicron coronavirus variant, according to the results of an initial laboratory study.  The data showed a third dose of the vaccine increases neutralizing antibodies by 25-fold compared with two doses, strengthening the case for and need for booster shots. The preliminary data suggest three doses provide a similar level of antibodies as is observed after two doses against other variants that emerged before Omicron, the companies said. Two vaccine doses showed a 25-fold reduction in neutralizing antibodies against Omicron compared with other variants, which they said suggested two doses “may not be sufficient” protection.  “Although two doses of the vaccine may still offer protection against severe disease caused by the Omicron strain, it’s clear from these preliminary data that protection is improved with a third dose of our vaccine,” Pfizer (ticker: PFE) CEO Albert Bourla said in a statement. The companies added that the development of an Omicron-specific vaccine was progressing and is expected to be available by March 2022, if such an adaptation ends up being needed. “The takeaways from Pfizer’s update underscore our belief that the durability of Pfizer’s vaccine sales for Covid-19 remain underappreciated by the Street,” Cantor Fitzgerald analysts said. They rate the stock as Overweight with a target price of $61, implying an 18% upside to Tuesday’s closing price.

Another study, published late Tuesday, suggested that Pfizer’s Covid-19 vaccine offers partial protection against the Omicron variant. The small South African laboratory-based study suggested that the variant escapes antibody immunity induced by the Pfizer-BioNTech vaccine but that “considerable immunity” is retained.  “It is likely that lesser vaccine-induced protection against infection and disease would be the result,” said Africa Health Research Institute’s executive director, Prof. Willem Hanekom. “Importantly most vaccinologists agree that the current vaccines will still protect against severe disease and death in the face of Omicron infection,” he added. The study was small, including blood samples from just 12 participants, but it is the first scientific data into the efficacy of vaccines against the Omicron variant. The loss of immune protection is “robust but not complete,” head of research Alex Sigal said, adding that a good booster shot would decrease the risk of infection, especially of more severe disease.  The study concluded that previous infection followed by vaccination of booster was likely to provide protection. It has been a volatile couple of weeks for Covid-19 vaccine makers, as investors battle to assess the impact of the Omicron variant while waiting for answers to crucial questions. Moderna (MRNA), Pfizer and Novavax (NVAX) were among the sharpest fallers in U.S. premarket trading on Wednesday. That is after plunging Monday and rallying on Tuesday. But Pfizer stock reversed course following the study results and was trading 0.4% higher.

Press release by Pfizer (Dec. 8, 2021) available at:

https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-provide-update-omicron-variant 

Moderna Inc (MRNA.O) said on Wednesday early human trial data shows that a third dose of either its current COVID-19 shot or an experimental new vaccine candidate increases immunity against variants of COVID-19 first found in Brazil and South Africa.  The booster shots, given to volunteers previously inoculated with Moderna's two-dose vaccine regimen, also boosted antibodies against the original version of COVID-19, Moderna said. The early data comes from a 40-person trial testing both Moderna's existing shot and a version developed to protect against the South African variant of COVID-19 called mRNA-1273.351. Moderna is also studying a shot that combines both the new and existing vaccine. The results show that while booster shots of either version of the vaccine increased antibodies against all of the variants of COVID-19 tested in the trial, the new booster had a bigger response against the South African variant than the original vaccine.

"We are encouraged by these new data, which reinforce our confidence that our booster strategy should be protective" against the newer variants of COVID-19, Stephane Bancel, Moderna's chief executive officer, said in a statement. Both booster shots were well tolerated, with side effects similar to what volunteers in previous studies experienced from the second dose of its vaccine, Moderna said. The new variants of COVID-19 first discovered in South Africa and Brazil are thought to be more resistant to existing vaccines. Both variants have been detected in the United States but comprise only a small fraction of U.S. cases so far, according to federal data last updated in April. Moderna’s study is looking at levels of antibodies in participants’ blood that combat COVID-19, an early indication that they will be protected against the virus. It first announced it was studying ways to protect against the variants of COVID-19 in February.  Moderna expects to share additional data soon on another potential booster shot that mixes its existing COVID-19 vaccine with the newly developed shot. The U.S. government scientists at the National Institute of Allergy and Infectious Diseases (NIAID) is conducting a separate early stage study of mRNA-1273.351, Moderna said.

Moderna's Press Release (May 5, 2021):

https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-positive-initial-booster-data-against-sars-cov