Your new post is loading...
Cellular RNAs are edited with high specificity using engineered ADAR-recruiting RNAs.
|
Scooped by BigField GEG Tech |
Scoop.it!
No comment yet.
Sign up to comment
In this article, the scientists present an approach, called leveraging endogenous ADAR for programmable editing of RNA (LEAPER), that employs short engineered ADAR-recruiting RNAs (arRNAs) to recruit native ADAR1 or ADAR2 enzymes to change a specific adenosine to inosine. They pave the way for a single-molecule system, LEAPER, enabling precise, efficient RNA editing with broad applicability for therapy and basic research.