Genetic Engineering Publications - GEG Tech top picks

Here, the scientists  have examined anti-leukemia potency of CART-cells targeting CD19 antigen using second generation CAR containing CD28-costimulatory domain cloned into piggyBac-transposon vector and patient-derived chemoresistant paediatric acute lymphoblastic leukaemia. Co-culture of leukaemia cells with bone marrow stroma cells reduced target cell loss suggesting that leukaemia cell mobilization into circulation may help to remove the protective effect of bone marrow stroma and increase the efficacy of CART-cell therapy.

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