Genetic Engineering Publications - GEG Tech top picks

Researchers explored the impact of dietary-derived trans-vaccenic acid (TVA) on effector cytotoxic T lymphocyte functions and anti-tumor immunity in in vivo settings using CRISPR. Overall, the results of the study showed that dietary trans-vaccenic acid enhances effector cytotoxic T lymphocyte activity and anti-tumor immunity in in vivo contexts. In contrast to intra-organism SCFA derived from intestinal microbes functioning as agonists of the G protein-coupled immunoregulatory receptor 43 (GPR43), extra-organism VAT reprogrammed CD8+ T lymphocytes by extrinsic regulation to inactivate GPR43. The results of the study contribute to a better understanding of the molecular links between nutrition and human pathophysiology, with implications for future research into the function of circulating nutrients in health and disease. Further research is needed to improve understanding of the effector pathways downstream of GPR43 and elucidate the underlying processes.

Cells from the rare individuals who naturally control HIV infection have been the focus of investigation for nearly 15 years with the aim of elucidating their specific features. Following research on the ANRS CO21 CODEX and CO6 PRIMO cohorts, scientists from the Institut Pasteur have described the characteristics of CD8 immune cells in these "HIV controller" subjects. The unique antiviral power of these immune cells can be attributed to an optimal metabolic program that confers persistence and the ability to react effectively against infected cells.

Metabolic plasticity of HIV-specific CD8+T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection