Genetic Engineering Publications - GEG Tech top picks

The authors describe a C. albicans CRISPR system that overcomes many of the obstacles to genetic engineering in this organism. The high frequency with which CRISPR-induced mutations can be directed to target genes enables easy isolation of homozygous gene knockouts, even without selection. This method transforms the ability to manipulate the genome of Candida and provides a new window into the biology of this pathogen.

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