Genetic Engineering Publications - GEG Tech top picks

Here, the authors developed an in vivo library-on-library methodology to simultaneously assess single guide RNA (sgRNA) activity across ~1,400 genomic loci. Their results and software (http://crispr.med.harvard.edu/sgRNAScorer) enable improved design of reagents, shed light on mechanisms of genome targeting, and provide a generalizable framework to study nucleic acid–nucleic acid interactions and biochemistry in high throughput.

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