In this work the authors demonstrated for the first time that the CRISPR/Cas9 system can be applied for modification of the duck enteritis virus (DEV) genome rapidly and efficiently, and that recombinant C-KCE-HA/PrM-E can serve as a potential candidate trivalent vaccine to prevent H5N1, DTMUV, and DEV infections in ducks.
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In this work the authors demonstrated for the first time that the CRISPR/Cas9 system can be applied for modification of the duck enteritis virus (DEV) genome rapidly and efficiently, and that recombinant C-KCE-HA/PrM-E can serve as a potential candidate trivalent vaccine to prevent H5N1, DTMUV, and DEV infections in ducks.