Genetic Engineering Publications - GEG Tech top picks

In this review, the authors will discuss the specific applications of gene-editing technologies in human HSPC, as informed by prior experience with gene addition strategies. HSPC are desirable but challenging targets; the specific mechanisms these cells evolved to protect themselves from DNA damage render them potentially more susceptible to oncogenesis, especially given their ability to self-renew and their long-term proliferative potential. They further review scientists’ experience with gene-editing technologies to date, focusing on strategies to move these techniques towards implementation in safe and effective clinical trials.