In this study, the authors show that human IDH mutant gliomas exhibit hypermethylation at cohesin and CCCTC-binding factor (CTCF)-binding sites, compromising binding of this methylation-sensitive insulator protein. They used the CRISPR system to disrupt CTCF and observed in IDH wild-type gliomaspheres the upregulation of PDGFRA and the increasing of proliferation
To get content containing either thought or leadership enter:
To get content containing both thought and leadership enter:
To get content containing the expression thought leadership enter:
You can enter several keywords and you can refine them whenever you want. Our suggestion engine uses more signals but entering a few keywords here will rapidly give you great content to curate.
In this study, the authors show that human IDH mutant gliomas exhibit hypermethylation at cohesin and CCCTC-binding factor (CTCF)-binding sites, compromising binding of this methylation-sensitive insulator protein. They used the CRISPR system to disrupt CTCF and observed in IDH wild-type gliomaspheres the upregulation of PDGFRA and the increasing of proliferation