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Progressive multifocal leukoencephalopathy (PML) is a debilitating disease resulting from infection of oligodendrocytes by the JC polyomavirus (JCPyV).
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In this study, the authors show that the CRISPR/Cas9 system can restrict the JC polyomavirus (JCPyV) life cycle in cultured cells. They utilized CRISPR/Cas9 to target the noncoding control region and the late gene open reading frame of the JCPyV genome. They found significant inhibition of virus replication and viral protein expression in cells recipient of Cas9 together with JCPyV-specific single-guide RNA delivered prior to or after JCPyV infection.