Genetic Engineering Publications - GEG Tech top picks
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A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs

A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs | Genetic Engineering Publications - GEG Tech top picks | Scoop.it
Light-sensitive regulators of protein kinases could offer valuable insights into intracellular signalling.
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Researchers at the Turku Centre for Biotechnology have invented new tools to decode and control signalling circuits in living cells with flashes of light. In principle, any cellular circuit can now be targeted with their method. Using this approach, they discovered that major biological signalling circuits can be made to resonate when driven at their resonant frequency

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ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition

ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition | Genetic Engineering Publications - GEG Tech top picks | Scoop.it
BigField GEG Tech's insight:

Although the MAPK pathway drives proliferation in RAS- or RAF-mutant cancers, small-molecule
RAF and MEK inhibitors have had limited success in treating RAS- or RAF-mutant cancers.
Using genome-scale CRISPR-Cas9 resistance screens, Wang et al. identify the AXN1L-CIC-ETS
transcription factor axis as a mediator of resistance to MAPK pathway inhibition.

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