Genetic Engineering Publications - GEG Tech top picks

Here, the authors demonstrate striking differences in super-enhancer transcriptional regulation of Nanog. In addition, they show that a distal super-enhancer differentially regulates multiple neighboring genes and that eRNAs produced at this super-enhancer selectively activate expression of one neighboring gene. Thus, eRNAs are critical to enhancer function. This study provides insight into the mechanism of transcribed enhancers in a cluster of co-regulated genes, specifically parsing out genes that cluster with a highly active transcribed enhancer versus a subset of genes the enhancer regulates.