The growth and structural formation of the human cortex can be modeled in vitro using cerebral organoids. In this article, Li, Muffat, and colleagues show that enhancing the PTEN-AKT signaling pathway leads to the generation of human cerebral organoids that are expanded in size and display surface folding.
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The growth and structural formation of the human cortex can be modeled in vitro using
cerebral organoids. In this article, Li, Muffat, and colleagues show that enhancing
the PTEN-AKT signaling pathway leads to the generation of human cerebral organoids
that are expanded in size and display surface folding.