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Genetic Engineering Publications - GEG Tech top picks
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In this study, the author compare ZFN and TALEN to target the insertion of a myelo-specific gp91phox cassette to AAVS1. They observe that TALENs were more efficient than ZFNs in generating correctly targeted iPSC colonies, but all corrected iPSC clones showed no signs of mutations at the top-ten predicted off-target sites of both nucleases. These data open the way to generate autologous, functionally corrected granulocytes with the TALEN system.
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