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Genetic Engineering Publications - GEG Tech top picks
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BigField GEG Tech's insight:
Efficient genome-editing tools are needed to correct patient-derived stem cells or model human disease. Hatada et al. report that low (0.4 Gy) doses of g-ray or X-ray radiation can increase recombination efficiency in cells by more than 30-fold when used in combination with zinc finger nucleases, transcription activator. 
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In this work, using human cultured cells, the authors demonstrate that a tardigrade-unique DNA-associating protein suppresses X-ray-induced DNA damage by ~40% and improves radiotolerance. These findings indicate the relevance of tardigrade-unique proteins to tolerability and tardigrades could be a bountiful source of new protection genes and mechanisms.