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Genetic Engineering Publications - GEG Tech top picks

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Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum - Nature Neuroscience | Genetic Engineering Publications - GEG Tech top picks | Scoop.it

From www.nature.com - April 13, 2015 2:42 AM

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The scientists observed thousands of chromatin accessibility changes as CGNs differentiated, and verified, using H3K27ac ChIP-seq, reporter gene assays and CRISPR-mediated activation, that many of these regions function as neuronal enhancers. They confirmed the association of Zic with these elements by ChIP-seq and found, using knockdown, that Zic1 and Zic2 are required for coordinating mature neuronal gene expression patterns.

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Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum - Nature Neuroscience