Targeted regulation of gene expression holds huge promise for biomedical research. In a series of recent publications ( Gilbert et al., 2014; Konermann et al., 2015; Zalatan et al., 2015 ), sophisticated, multiplex-compatible transcriptional activator systems based on the CRISPR-Cas9 technology and genome-scale libraries advance the field toward whole-transcriptome control.
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Targeted regulation of gene expression holds huge promise for biomedical research. In a series of recent publications ( Gilbert et al., 2014; Konermann et al., 2015; Zalatan et al., 2015 ), sophisticated, multiplex-compatible transcriptional activator systems based on the CRISPR-Cas9 technology and genome-scale libraries advance the field toward whole-transcriptome control.
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